Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome)
Mutations in the GLIS3 gene encoding the GLIS3 transcription factor are cause of a rare syndromic form of neonatal diabetes mellitus (NDM) with congenital hypothyroidism. Additional features include congenital glaucoma, hepatic fibrosis, polycystic kidneys, developmental delay and other anomalies. T...
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Endocrinology Research Centre
2022-03-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/12826 |
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| author | Yu. V. Tikhonovich L. G. Chernich I. N. Velikanov V. M. Polyakova E. V. Vasilyev V. M. Petrov E. V. Shreder Е. V. Glavatskich A. N. Tyulpakov |
| author_facet | Yu. V. Tikhonovich L. G. Chernich I. N. Velikanov V. M. Polyakova E. V. Vasilyev V. M. Petrov E. V. Shreder Е. V. Glavatskich A. N. Tyulpakov |
| author_sort | Yu. V. Tikhonovich |
| collection | DOAJ |
| description | Mutations in the GLIS3 gene encoding the GLIS3 transcription factor are cause of a rare syndromic form of neonatal diabetes mellitus (NDM) with congenital hypothyroidism. Additional features include congenital glaucoma, hepatic fibrosis, polycystic kidneys, developmental delay and other anomalies. This disease in foreign literature is called NDH-syndrome (Neonatal diabetes and Hypothyroidism syndrome).We present the description of a patient with this syndrome with novel homozygous GLIS3 mutation.Our patient is a female, who was born with a weight of 1680 gr, length of 44 cm to consanguineous parents. She developed diabetes on 2 day after birth, requiring continuous intravenous insulin. On day 5 of life hypothyroidism was identified. Thyroid anatomy was normal on ultrasound scan. NDH syndrome was suspected.Genetic analysis revealed a novel homozygous mutation c.1836delT, p.Ser612ArgfsTer33 in exon 5 in GLIS3 gene.To date, the patient is followed up for 4 years in total. Currently, growth retardation, psychomotor and speech development persist. Carbohydrate metabolism and thyroid profile has been subcompensated against the background of replacement therapy. No other components of the syndrome have been identified.In this report, we have demonstrated the features of the neonatal diabetes mellitus in a patient with a defect in the GLIS3 gene. Early genetic verification of the diagnosis contributes to the timely starting of personalized therapy, can improve the quality of life of such patients, and, given the nature of inheritance, is necessary for medical genetic counseling of the family. |
| format | Article |
| id | doaj-art-15276206fcaa42249961e40a5ce1fb10 |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-15276206fcaa42249961e40a5ce1fb102025-08-20T03:09:04ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782022-03-01251818810.14341/DM1282610928Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome)Yu. V. Tikhonovich0L. G. Chernich1I. N. Velikanov2V. M. Polyakova3E. V. Vasilyev4V. M. Petrov5E. V. Shreder6Е. V. Glavatskich7A. N. Tyulpakov8Sechenov First Moscow State Medical University; Morozov children’s city hospitalState Autonomous Healthcare Institution Sverdlovsk Regional children’s clinical hospitalState Autonomous Healthcare Institution Sverdlovsk Regional children’s clinical hospitalState Autonomous Healthcare Institution Sverdlovsk Regional children’s clinical hospitalEndocrinology Research CentreEndocrinology Research CentreMorozov children’s city hospitalChildren City HospitalPirogov Russian National Research Medical University; Academician N.P. Bochkov Research Centre of Medical Genetics (RCMG) of the Russian Academy of SciencesMutations in the GLIS3 gene encoding the GLIS3 transcription factor are cause of a rare syndromic form of neonatal diabetes mellitus (NDM) with congenital hypothyroidism. Additional features include congenital glaucoma, hepatic fibrosis, polycystic kidneys, developmental delay and other anomalies. This disease in foreign literature is called NDH-syndrome (Neonatal diabetes and Hypothyroidism syndrome).We present the description of a patient with this syndrome with novel homozygous GLIS3 mutation.Our patient is a female, who was born with a weight of 1680 gr, length of 44 cm to consanguineous parents. She developed diabetes on 2 day after birth, requiring continuous intravenous insulin. On day 5 of life hypothyroidism was identified. Thyroid anatomy was normal on ultrasound scan. NDH syndrome was suspected.Genetic analysis revealed a novel homozygous mutation c.1836delT, p.Ser612ArgfsTer33 in exon 5 in GLIS3 gene.To date, the patient is followed up for 4 years in total. Currently, growth retardation, psychomotor and speech development persist. Carbohydrate metabolism and thyroid profile has been subcompensated against the background of replacement therapy. No other components of the syndrome have been identified.In this report, we have demonstrated the features of the neonatal diabetes mellitus in a patient with a defect in the GLIS3 gene. Early genetic verification of the diagnosis contributes to the timely starting of personalized therapy, can improve the quality of life of such patients, and, given the nature of inheritance, is necessary for medical genetic counseling of the family.https://www.dia-endojournals.ru/jour/article/view/12826neonatal diabetes mellitusgene glis3ndh-syndromecongenital hypothyroidism |
| spellingShingle | Yu. V. Tikhonovich L. G. Chernich I. N. Velikanov V. M. Polyakova E. V. Vasilyev V. M. Petrov E. V. Shreder Е. V. Glavatskich A. N. Tyulpakov Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) Сахарный диабет neonatal diabetes mellitus gene glis3 ndh-syndrome congenital hypothyroidism |
| title | Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) |
| title_full | Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) |
| title_fullStr | Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) |
| title_full_unstemmed | Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) |
| title_short | Novel GLIS3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism (NDH-syndrome) |
| title_sort | novel glis3 mutation in patient with neonatal diabetes mellitus and congenital hypothyroidism ndh syndrome |
| topic | neonatal diabetes mellitus gene glis3 ndh-syndrome congenital hypothyroidism |
| url | https://www.dia-endojournals.ru/jour/article/view/12826 |
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