Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy
Abstract Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can...
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BMC
2024-11-01
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| Series: | Biomarker Research |
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| Online Access: | https://doi.org/10.1186/s40364-024-00687-6 |
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| author | Dan-Feng Cao Xin-Yu Zhou Qian Guo Ming-Yao Xiang Mei-Hua Bao Bin-Sheng He Xiao-Yuan Mao |
| author_facet | Dan-Feng Cao Xin-Yu Zhou Qian Guo Ming-Yao Xiang Mei-Hua Bao Bin-Sheng He Xiao-Yuan Mao |
| author_sort | Dan-Feng Cao |
| collection | DOAJ |
| description | Abstract Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it is of urgent need to explore other potential mechanism to develop a novel approach to delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), the versatile epigenetic regulators responsible for gene transcription via binding histones or non-histone substrates, have grabbed considerable attention in drug discovery. There are also substantial evidences supporting that aberrant expressions and/activities of HDAC isoforms are reported in epilepsy and HDAC inhibitors (HDACi) have been successfully utilized for therapeutic purposes in this condition. However, the specific mechanisms underlying the role of HDACs in epileptic progression have not been fully understood. Herein, we reviewed the basic information of HDACs, summarized the recent findings associated with the roles of diverse HDAC subunits in epilepsy and discussed the potential regulatory mechanisms by which HDACs affected the development of epilepsy. Additionally, we also provided a brief discussion on the potential of HDACs as promising therapeutic targets for epilepsy treatment, serving as a valuable reference for basic study and clinical translation in epilepsy field. |
| format | Article |
| id | doaj-art-151ee8f4a5f64891b36e6d873676dc4b |
| institution | OA Journals |
| issn | 2050-7771 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj-art-151ee8f4a5f64891b36e6d873676dc4b2025-08-20T02:22:26ZengBMCBiomarker Research2050-77712024-11-0112111810.1186/s40364-024-00687-6Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsyDan-Feng Cao0Xin-Yu Zhou1Qian Guo2Ming-Yao Xiang3Mei-Hua Bao4Bin-Sheng He5Xiao-Yuan Mao6Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical UniversityDepartment of Neurosurgery, The Affiliated Hospital of Kangda College of Nanjing Medical UniversityDepartment of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityDepartment of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical UniversityHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical UniversityDepartment of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics and National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South UniversityAbstract Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons and poses a great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it is of urgent need to explore other potential mechanism to develop a novel approach to delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), the versatile epigenetic regulators responsible for gene transcription via binding histones or non-histone substrates, have grabbed considerable attention in drug discovery. There are also substantial evidences supporting that aberrant expressions and/activities of HDAC isoforms are reported in epilepsy and HDAC inhibitors (HDACi) have been successfully utilized for therapeutic purposes in this condition. However, the specific mechanisms underlying the role of HDACs in epileptic progression have not been fully understood. Herein, we reviewed the basic information of HDACs, summarized the recent findings associated with the roles of diverse HDAC subunits in epilepsy and discussed the potential regulatory mechanisms by which HDACs affected the development of epilepsy. Additionally, we also provided a brief discussion on the potential of HDACs as promising therapeutic targets for epilepsy treatment, serving as a valuable reference for basic study and clinical translation in epilepsy field.https://doi.org/10.1186/s40364-024-00687-6EpilepsyEpigenetic targetsHistone deacetylasesInhibitorsTherapy |
| spellingShingle | Dan-Feng Cao Xin-Yu Zhou Qian Guo Ming-Yao Xiang Mei-Hua Bao Bin-Sheng He Xiao-Yuan Mao Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy Biomarker Research Epilepsy Epigenetic targets Histone deacetylases Inhibitors Therapy |
| title | Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy |
| title_full | Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy |
| title_fullStr | Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy |
| title_full_unstemmed | Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy |
| title_short | Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy |
| title_sort | unveiling the role of histone deacetylases in neurological diseases focus on epilepsy |
| topic | Epilepsy Epigenetic targets Histone deacetylases Inhibitors Therapy |
| url | https://doi.org/10.1186/s40364-024-00687-6 |
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