Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals
Abstract Mechanical properties and integrity of biodegradable Zn alloys during degradation holds significant importance. In this study, a Zn-Mg-Mn alloy with tensile strength of 414 MPa and an elongation of 26% was developed. The strength contributions of as-extruded Zn alloy from grain boundary str...
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| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-78842-0 |
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| author | Chengwu Lu Chao Song Yunlong Yu Linhai Yang Wu Zheng Fenqi Luo Yuhua Xiao Jun Luo Jie Xu |
| author_facet | Chengwu Lu Chao Song Yunlong Yu Linhai Yang Wu Zheng Fenqi Luo Yuhua Xiao Jun Luo Jie Xu |
| author_sort | Chengwu Lu |
| collection | DOAJ |
| description | Abstract Mechanical properties and integrity of biodegradable Zn alloys during degradation holds significant importance. In this study, a Zn-Mg-Mn alloy with tensile strength of 414 MPa and an elongation of 26% was developed. The strength contributions of as-extruded Zn alloy from grain boundary strengthening, precipitation strengthening, and second phase strengthening. Degradation of the Zn alloy in Hank’s solution exhibited a decreasing trend with prolonged immersion, eventually stabilizing at 16 μm/year. Corrosion morphology analysis revealed that the corrosion modes transformed from pitting corrosion to severely localized corrosion with prolonged immersion time, eventually lead to formation of large holes. Although the tensile strength of the Zn alloys remained relatively unchanged following varied immersion time, a substantial decrease in elongation was observed. The decreased elongation primarily attributed to the formation of surface corrosion pits or holes, exacerbating crack propagation during tension. Biocompatibility assessments of Zn alloys demonstrated that a 50% concentration of Zn alloy leach solution cultured with C3H10 and RMSC cells yielded cellular activity exceeding 80%, indicating excellent cytocompatibility. Alkaline phosphatase (ALP) and alizarin red staining results further underscored the remarkable early and late osteogenic properties exhibited by Zn-Mg-Mn alloy. |
| format | Article |
| id | doaj-art-1515ac29f51c4f76a32d5163953df3aa |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-1515ac29f51c4f76a32d5163953df3aa2025-08-20T02:39:40ZengNature PortfolioScientific Reports2045-23222024-12-0114111410.1038/s41598-024-78842-0Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metalsChengwu Lu0Chao Song1Yunlong Yu2Linhai Yang3Wu Zheng4Fenqi Luo5Yuhua Xiao6Jun Luo7Jie Xu8Shengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityShengli Clinical Medical College of Fujian Medical UniversityAbstract Mechanical properties and integrity of biodegradable Zn alloys during degradation holds significant importance. In this study, a Zn-Mg-Mn alloy with tensile strength of 414 MPa and an elongation of 26% was developed. The strength contributions of as-extruded Zn alloy from grain boundary strengthening, precipitation strengthening, and second phase strengthening. Degradation of the Zn alloy in Hank’s solution exhibited a decreasing trend with prolonged immersion, eventually stabilizing at 16 μm/year. Corrosion morphology analysis revealed that the corrosion modes transformed from pitting corrosion to severely localized corrosion with prolonged immersion time, eventually lead to formation of large holes. Although the tensile strength of the Zn alloys remained relatively unchanged following varied immersion time, a substantial decrease in elongation was observed. The decreased elongation primarily attributed to the formation of surface corrosion pits or holes, exacerbating crack propagation during tension. Biocompatibility assessments of Zn alloys demonstrated that a 50% concentration of Zn alloy leach solution cultured with C3H10 and RMSC cells yielded cellular activity exceeding 80%, indicating excellent cytocompatibility. Alkaline phosphatase (ALP) and alizarin red staining results further underscored the remarkable early and late osteogenic properties exhibited by Zn-Mg-Mn alloy.https://doi.org/10.1038/s41598-024-78842-0Biodegradable zn alloysMechanical propertiesMechanical integrityBiocompatibility |
| spellingShingle | Chengwu Lu Chao Song Yunlong Yu Linhai Yang Wu Zheng Fenqi Luo Yuhua Xiao Jun Luo Jie Xu Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals Scientific Reports Biodegradable zn alloys Mechanical properties Mechanical integrity Biocompatibility |
| title | Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| title_full | Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| title_fullStr | Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| title_full_unstemmed | Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| title_short | Biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| title_sort | biodegradable zinc alloys with high strength and suitable mechanical integrity as bone repair metals |
| topic | Biodegradable zn alloys Mechanical properties Mechanical integrity Biocompatibility |
| url | https://doi.org/10.1038/s41598-024-78842-0 |
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