ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium
On 24 February 2024, Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygienists, and other professionals met (live or online) to discuss controversial issues about medication-related osteonecrosis of the jaw (MRONJ). One section hosted international ex...
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2025-04-01
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| author | Vittorio Fusco Martina Coppini Gaetano La Mantia Paolo G. Arduino Fortunato Buttacavoli Alessio Gambino Francesco M. Erovigni Alberto Bedogni Giuseppina Campisi |
| author_facet | Vittorio Fusco Martina Coppini Gaetano La Mantia Paolo G. Arduino Fortunato Buttacavoli Alessio Gambino Francesco M. Erovigni Alberto Bedogni Giuseppina Campisi |
| author_sort | Vittorio Fusco |
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| description | On 24 February 2024, Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygienists, and other professionals met (live or online) to discuss controversial issues about medication-related osteonecrosis of the jaw (MRONJ). One section hosted international experts who gave lectures about MRONJ experiences in North America, Europe, and Italy. A second section summarized the principal points of an Italian MRONJ position paper published in February 2024 by experts from the Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF). The following section collates expert opinions about open issues and required fields of research: different definitions of MRONJ and impact on staging; the assessment of individual MRONJ risk before the start of antiresorptive therapy; surgery and implantology in patients at risk for MRONJ; cancer patients without metastases and prevention of cancer-treatment-induced bone Loss (CTIBL); the role of dental hygiene professionals; combined (medical and surgical) and surgical therapy for MRONJ in-patients and out-patients; and legal aspects and claims related to MRONJ diagnosis and treatment. Scientific contributions from hospitals and universities all over Italy were presented in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: the conference confirmed the importance of the adequate imaging study of bone in the diagnosis and staging of MRONJ cases, the role of surgery in MRONJ treatment, and the value of oral hygiene in the MRONJ prevention. |
| format | Article |
| id | doaj-art-150c314234e64ccbb12e806cf0d472d9 |
| institution | Kabale University |
| issn | 2673-6373 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Oral |
| spelling | doaj-art-150c314234e64ccbb12e806cf0d472d92025-08-20T03:27:21ZengMDPI AGOral2673-63732025-04-01522510.3390/oral5020025ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian SymposiumVittorio Fusco0Martina Coppini1Gaetano La Mantia2Paolo G. Arduino3Fortunato Buttacavoli4Alessio Gambino5Francesco M. Erovigni6Alberto Bedogni7Giuseppina Campisi8Translational Medicine Unit, DAIRI Department of Integration, Research and Innovation, Azienda Ospedaliera-Universitaria “SS Antonio E Biagio e Cesare Arrigo”, 15121 Alessandria, ItalyUnit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, 90127 Palermo, ItalyUnit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, 90127 Palermo, ItalyUnit of Oral Rehabilitation, Maxillo-Facial Prosthodontics and Dental Implantology, Department of Surgical Science, CIR Dental School, 10126 Turin, ItalyUnit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, 90127 Palermo, ItalyUnit of Oral Rehabilitation, Maxillo-Facial Prosthodontics and Dental Implantology, Department of Surgical Science, CIR Dental School, 10126 Turin, ItalyUnit of Oral Rehabilitation, Maxillo-Facial Prosthodontics and Dental Implantology, Department of Surgical Science, CIR Dental School, 10126 Turin, ItalyRegional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padua, 35128 Padua, ItalyUnit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, 90127 Palermo, ItalyOn 24 February 2024, Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygienists, and other professionals met (live or online) to discuss controversial issues about medication-related osteonecrosis of the jaw (MRONJ). One section hosted international experts who gave lectures about MRONJ experiences in North America, Europe, and Italy. A second section summarized the principal points of an Italian MRONJ position paper published in February 2024 by experts from the Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF). The following section collates expert opinions about open issues and required fields of research: different definitions of MRONJ and impact on staging; the assessment of individual MRONJ risk before the start of antiresorptive therapy; surgery and implantology in patients at risk for MRONJ; cancer patients without metastases and prevention of cancer-treatment-induced bone Loss (CTIBL); the role of dental hygiene professionals; combined (medical and surgical) and surgical therapy for MRONJ in-patients and out-patients; and legal aspects and claims related to MRONJ diagnosis and treatment. Scientific contributions from hospitals and universities all over Italy were presented in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: the conference confirmed the importance of the adequate imaging study of bone in the diagnosis and staging of MRONJ cases, the role of surgery in MRONJ treatment, and the value of oral hygiene in the MRONJ prevention.https://www.mdpi.com/2673-6373/5/2/25osteonecrosisjawjawsosteonecrosis of jawbisphosphonatedenosumab |
| spellingShingle | Vittorio Fusco Martina Coppini Gaetano La Mantia Paolo G. Arduino Fortunato Buttacavoli Alessio Gambino Francesco M. Erovigni Alberto Bedogni Giuseppina Campisi ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium Oral osteonecrosis jaw jaws osteonecrosis of jaw bisphosphonate denosumab |
| title | ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium |
| title_full | ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium |
| title_fullStr | ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium |
| title_full_unstemmed | ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium |
| title_short | ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium |
| title_sort | onj mronj update 2024 osteonecrosis of the jaw related to bisphosphonates and other drugs prevention diagnosis pharmacovigilance treatment a national italian symposium |
| topic | osteonecrosis jaw jaws osteonecrosis of jaw bisphosphonate denosumab |
| url | https://www.mdpi.com/2673-6373/5/2/25 |
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