Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients
Background: Drug-resistant tuberculosis is an airborne chronic infectious disease that has evolved resistance to at least two anti-TB medications (isoniazid and rifampin). For the drug-resistant tuberculosis epidemic to be controlled, it is essential that patients be cured. However, therapeutic fai...
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College of Pharmacy / Mustansiriyah University
2025-01-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1109 |
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| author | Noor Alaa Jasim Manal Khalid Abdulridha Ahmed Asmar Mankhy Ahmed Hadi Tarish |
| author_facet | Noor Alaa Jasim Manal Khalid Abdulridha Ahmed Asmar Mankhy Ahmed Hadi Tarish |
| author_sort | Noor Alaa Jasim |
| collection | DOAJ |
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Background: Drug-resistant tuberculosis is an airborne chronic infectious disease that has evolved resistance to at least two anti-TB medications (isoniazid and rifampin). For the drug-resistant tuberculosis epidemic to be controlled, it is essential that patients be cured. However, therapeutic failure is often caused by patients who don't adhere to their prescribed regimen.
Incomplete treatment facilitates the spread of multidrug-resistant tuberculosis and the subsequent emergence of severely drug-resistant TB. It is crucial to determine the prevalence of pharmacological non-adherence among these patients and to know the reasons for this non-adherence.
Result: The study involved a total of 67 drug-resistant tuberculosis patients, and the duration of their treatment was 14 weeks, mostly males, with a majority being urban residents. within the first two weeks, only 1 patient interrupted the treatment course for a short term. At six weeks (6%) of patients interrupted the course, within the ten weeks, there was no interruption and 100% of adhere to treatment was observed. At fourteen weeks, (14.9%) of the patients interrupted the course. The patients who interrupted to treatment were mostly due to far residence because the TB institute was the only institute in Iraq where patients treated and diagnosed in Baghdad, others of them were causeless interrupted their treatment, and fewer due to adverse drug events such as anemia due to took linezolid drug and arthralgia because of levofloxacin drug. There was not a statistically significant difference between those who adhered to the correct dose (the correct count number of pills) and those who adhered to a low dose (low count number of pills) with demographic data.
Conclusion: Patient interrupting the treatment course was noticed mostly in the six and fourteen weeks, patient characteristics did not impact their adherence to the proper dose.
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| format | Article |
| id | doaj-art-150bc52ebf2f42149946312a9c88dcdd |
| institution | Kabale University |
| issn | 1815-0993 2959-183X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj-art-150bc52ebf2f42149946312a9c88dcdd2025-01-24T13:47:27ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2025-01-0125110.32947/ajps.v25i1.1109Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi PatientsNoor Alaa Jasim0Manal Khalid Abdulridha1Ahmed Asmar Mankhy2Ahmed Hadi Tarish3Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Baghdad, IraqDepartment of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq The National Tuberculosis Institute, Baghdad, IraqRoyal Oldham General Hospital, Greater Manchester, England، UK Background: Drug-resistant tuberculosis is an airborne chronic infectious disease that has evolved resistance to at least two anti-TB medications (isoniazid and rifampin). For the drug-resistant tuberculosis epidemic to be controlled, it is essential that patients be cured. However, therapeutic failure is often caused by patients who don't adhere to their prescribed regimen. Incomplete treatment facilitates the spread of multidrug-resistant tuberculosis and the subsequent emergence of severely drug-resistant TB. It is crucial to determine the prevalence of pharmacological non-adherence among these patients and to know the reasons for this non-adherence. Result: The study involved a total of 67 drug-resistant tuberculosis patients, and the duration of their treatment was 14 weeks, mostly males, with a majority being urban residents. within the first two weeks, only 1 patient interrupted the treatment course for a short term. At six weeks (6%) of patients interrupted the course, within the ten weeks, there was no interruption and 100% of adhere to treatment was observed. At fourteen weeks, (14.9%) of the patients interrupted the course. The patients who interrupted to treatment were mostly due to far residence because the TB institute was the only institute in Iraq where patients treated and diagnosed in Baghdad, others of them were causeless interrupted their treatment, and fewer due to adverse drug events such as anemia due to took linezolid drug and arthralgia because of levofloxacin drug. There was not a statistically significant difference between those who adhered to the correct dose (the correct count number of pills) and those who adhered to a low dose (low count number of pills) with demographic data. Conclusion: Patient interrupting the treatment course was noticed mostly in the six and fourteen weeks, patient characteristics did not impact their adherence to the proper dose. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1109adherencenon-adherenceoral regimen for drug-resistant TB treatment |
| spellingShingle | Noor Alaa Jasim Manal Khalid Abdulridha Ahmed Asmar Mankhy Ahmed Hadi Tarish Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients Al-Mustansiriyah Journal of Pharmaceutical Sciences adherence non-adherence oral regimen for drug-resistant TB treatment |
| title | Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients |
| title_full | Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients |
| title_fullStr | Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients |
| title_full_unstemmed | Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients |
| title_short | Assessment of Patients Adherence to Oral Regimen of Drug-Resistant Tuberculosis among Iraqi Patients |
| title_sort | assessment of patients adherence to oral regimen of drug resistant tuberculosis among iraqi patients |
| topic | adherence non-adherence oral regimen for drug-resistant TB treatment |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1109 |
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