Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study
"Purpose: Recurrent cystitis, particularly common in women, substantially diminishes patient quality of life and represents a major clinical practice and public health burden. Increasing development of resistance to antibiotics has encouraged the search for alternative treatments. The benefits...
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| Format: | Article |
| Language: | English |
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Korean Urological Association
2025-01-01
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| Series: | Investigative and Clinical Urology |
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| Online Access: | https://www.icurology.org/pdf/10.4111/icu.20240092 |
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| author | Samira Ait Abdellah Anne Leblanc Quentin Dauchet Claude Blondeau Jean Marc Bohbot |
| author_facet | Samira Ait Abdellah Anne Leblanc Quentin Dauchet Claude Blondeau Jean Marc Bohbot |
| author_sort | Samira Ait Abdellah |
| collection | DOAJ |
| description | "Purpose: Recurrent cystitis, particularly common in women, substantially diminishes patient quality of life and represents a major clinical practice and public health burden. Increasing development of resistance to antibiotics has encouraged the search for alternative treatments. The benefits of a food supplement associating two Lactobacillus strains with proanthocyanidin A-rich cranberry and cinnamon extracts were evaluated in 80 women with a history of cystitis recurrence.
Materials and Methods: Post-inclusion recurrence frequency was compared between women taking the investigated supplement daily for 6 months and non-supplemented women, based on patient-completed Acute Cystitis Symptom Score (ACSS) questionnaires.
Results: Two-thirds (64.9%) of supplemented women experienced no further episodes of cystitis during the first 6 months of the study compared to only one-third (31.6%) of non-supplemented women (p=0.004), the difference between the two groups being significant from 3 months onward. ACSS scores revealed significantly fewer and less severe urinary symptoms in supplemented women, as well as a significantly reduced impact of these symptoms on quality of life (p<0.0001).
Conclusions: The results shown by extensive data on women suffering from recurrent cystitis, collected over 8 months, indicate that taking the tested supplement daily for 6 months can provide significant benefits in terms of recurrence frequency, symptoms, and quality of life. The study is registered on the ClinicalTrials.gov site under the identifier NCT04987164."
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| format | Article |
| id | doaj-art-1503db343c4c4af89faf0cd0a95c0d5d |
| institution | Kabale University |
| issn | 2466-0493 2466-054X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Urological Association |
| record_format | Article |
| series | Investigative and Clinical Urology |
| spelling | doaj-art-1503db343c4c4af89faf0cd0a95c0d5d2025-01-09T09:40:40ZengKorean Urological AssociationInvestigative and Clinical Urology2466-04932466-054X2025-01-01661364610.4111/icu.20240092Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled studySamira Ait Abdellah0https://orcid.org/0000-0001-8649-4598Anne Leblanc1https://orcid.org/0009-0002-7803-6938 Quentin Dauchet2https://orcid.org/0009-0002-2352-7019Claude Blondeau3https://orcid.org/0000-0002-0833-4633Jean Marc Bohbot4https://orcid.org/0000-0002-9621-4745PiLeJe Laboratoire, Paris, France.PiLeJe Laboratoire, Paris, France.PiLeJe Laboratoire, Paris, France.PiLeJe Laboratoire, Paris, France.Institut Alfred Fournier, Paris, France."Purpose: Recurrent cystitis, particularly common in women, substantially diminishes patient quality of life and represents a major clinical practice and public health burden. Increasing development of resistance to antibiotics has encouraged the search for alternative treatments. The benefits of a food supplement associating two Lactobacillus strains with proanthocyanidin A-rich cranberry and cinnamon extracts were evaluated in 80 women with a history of cystitis recurrence. Materials and Methods: Post-inclusion recurrence frequency was compared between women taking the investigated supplement daily for 6 months and non-supplemented women, based on patient-completed Acute Cystitis Symptom Score (ACSS) questionnaires. Results: Two-thirds (64.9%) of supplemented women experienced no further episodes of cystitis during the first 6 months of the study compared to only one-third (31.6%) of non-supplemented women (p=0.004), the difference between the two groups being significant from 3 months onward. ACSS scores revealed significantly fewer and less severe urinary symptoms in supplemented women, as well as a significantly reduced impact of these symptoms on quality of life (p<0.0001). Conclusions: The results shown by extensive data on women suffering from recurrent cystitis, collected over 8 months, indicate that taking the tested supplement daily for 6 months can provide significant benefits in terms of recurrence frequency, symptoms, and quality of life. The study is registered on the ClinicalTrials.gov site under the identifier NCT04987164." https://www.icurology.org/pdf/10.4111/icu.20240092cinnamoncranberrylactobacillusproanthocyanidinsprobiotic |
| spellingShingle | Samira Ait Abdellah Anne Leblanc Quentin Dauchet Claude Blondeau Jean Marc Bohbot Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study Investigative and Clinical Urology cinnamon cranberry lactobacillus proanthocyanidins probiotic |
| title | Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study |
| title_full | Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study |
| title_fullStr | Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study |
| title_full_unstemmed | Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study |
| title_short | Effects of a supplement associating Lactobacillus strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study |
| title_sort | effects of a supplement associating lactobacillus strains and proanthocyanidin rich plant extracts against recurrent uncomplicated urinary tract infections a prospective controlled study |
| topic | cinnamon cranberry lactobacillus proanthocyanidins probiotic |
| url | https://www.icurology.org/pdf/10.4111/icu.20240092 |
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