Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives
New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the b...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2015/982404 |
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| Summary: | New heterocyclic compounds spiroderivatives of
allopurinol of biological interest were prepared from
allopurinol via thionation and 1,3-dipolar
cycloaddition and were produced in high to excellent
yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS).
The antibacterial activity of the synthesized products was studied
using bacterial strains: Staphylococcus aureus,
Enterococcus faecalis, Escherichia
coli, and Pseudomonas aeruginosa.
Compounds having an ethyl group showed the best activity with MIC
value of 31.25 µg/mL against Staphylococcus
aureus and Streptococcus fasciens. |
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| ISSN: | 2090-9063 2090-9071 |