Suppress or Not to Suppress … CRAFT It: A Targeted Metabolomics Case Study Extracting Essential Biomarker Signals Directly from the Full <sup>1</sup>H NMR Spectra of Horse Serum Samples

Suppress or Not to Suppress … CRAFT It: A Targeted Metabolomics Case Study Extracting Essential Biomarker Signals Directly from the Full <sup>1</sup>H NMR Spectra of Horse Serum Samples

<b>Background</b>: There are a few very specific inflammation biomarkers in blood, namely lipoprotein NMe<sup>+</sup> signals of protein clusters (GlycA and GlycB) and a composite resonance of phospholipids (SPC). The relative integrals of these resonances provide clear indic...

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Bibliographic Details
Main Authors: James Chen, Ayelet Yablon, Christina Metaxas, Matheus Guedin, Joseph Hu, Kenith Conover, Merrill Simpson, Sarah L. Ralston, Krish Krishnamurthy, István Pelczer
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Metabolites
Subjects:
biomarkers
targeted metabolomics
NMR
signal processing
CRAFT
inflammation
Online Access:https://www.mdpi.com/2218-1989/15/6/387
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