Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration
Sunlight exposure is recognized as a risk factor for the development of age-related macular degeneration (AMD), a common neurodegenerative retinal disease in the elderly. Specifically, the blue light wavelengths within sunlight can negatively impact the physiology of light-sensitive retinal cells, i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1509434/full |
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| author | Harshini Chakravarthy Vasil Georgyev Cole Wagen Amir Hosseini Joanne Matsubara |
| author_facet | Harshini Chakravarthy Vasil Georgyev Cole Wagen Amir Hosseini Joanne Matsubara |
| author_sort | Harshini Chakravarthy |
| collection | DOAJ |
| description | Sunlight exposure is recognized as a risk factor for the development of age-related macular degeneration (AMD), a common neurodegenerative retinal disease in the elderly. Specifically, the blue light wavelengths within sunlight can negatively impact the physiology of light-sensitive retinal cells, including retinal pigmented epithelium (RPE) and photoreceptors. This review explores blue light-induced retinal degeneration, emphasizing the structural and functional impairments in RPE. The initial section provides a brief overview of blue light’s effects on photoreceptors, followed by a comprehensive analysis of its detrimental impact on RPE. In vitro studies reveal that blue light exposure induces morphological alterations and functional impairments in RPE, including reduced phagocytic activity, disrupted secretion of neurotrophic factors, and compromised barrier function. Mechanisms of retinal damage, including oxidative stress, inflammation, lipofuscin accumulation, mitochondrial dysfunction and ER stress in RPE, are also explored. The strengths and limitations of in vitro, animal and ex vivo models for studying blue light exposure are discussed, with recommendations for improving reproducibility in future studies. |
| format | Article |
| id | doaj-art-14f4e26507e84e52950fce2f482b86c0 |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-14f4e26507e84e52950fce2f482b86c02025-08-20T01:57:49ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-12-011610.3389/fnagi.2024.15094341509434Blue light-induced phototoxicity in retinal cells: implications in age-related macular degenerationHarshini ChakravarthyVasil GeorgyevCole WagenAmir HosseiniJoanne MatsubaraSunlight exposure is recognized as a risk factor for the development of age-related macular degeneration (AMD), a common neurodegenerative retinal disease in the elderly. Specifically, the blue light wavelengths within sunlight can negatively impact the physiology of light-sensitive retinal cells, including retinal pigmented epithelium (RPE) and photoreceptors. This review explores blue light-induced retinal degeneration, emphasizing the structural and functional impairments in RPE. The initial section provides a brief overview of blue light’s effects on photoreceptors, followed by a comprehensive analysis of its detrimental impact on RPE. In vitro studies reveal that blue light exposure induces morphological alterations and functional impairments in RPE, including reduced phagocytic activity, disrupted secretion of neurotrophic factors, and compromised barrier function. Mechanisms of retinal damage, including oxidative stress, inflammation, lipofuscin accumulation, mitochondrial dysfunction and ER stress in RPE, are also explored. The strengths and limitations of in vitro, animal and ex vivo models for studying blue light exposure are discussed, with recommendations for improving reproducibility in future studies.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1509434/fullphototoxicityretinal inflammationphotoreceptorsretinal pigmented epithelial (RPE) cellsage-related macular degeneration (AMD)blue light exposure |
| spellingShingle | Harshini Chakravarthy Vasil Georgyev Cole Wagen Amir Hosseini Joanne Matsubara Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration Frontiers in Aging Neuroscience phototoxicity retinal inflammation photoreceptors retinal pigmented epithelial (RPE) cells age-related macular degeneration (AMD) blue light exposure |
| title | Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration |
| title_full | Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration |
| title_fullStr | Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration |
| title_full_unstemmed | Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration |
| title_short | Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration |
| title_sort | blue light induced phototoxicity in retinal cells implications in age related macular degeneration |
| topic | phototoxicity retinal inflammation photoreceptors retinal pigmented epithelial (RPE) cells age-related macular degeneration (AMD) blue light exposure |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1509434/full |
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