Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude
Abstract Intermittent hypoxia has been used to enhance oxygen delivery in athletes and patients; however, it is unclear whether acute exposure is sufficient to elicit lasting physiologic adaptation(s). The purpose of this study was to evaluate physiologic response(s) to hypobaric‐hypoxic (HH) exerci...
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Wiley
2025-04-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70195 |
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| author | Kelsey E. Joyce M. Travis Byrd Courtney M. Wheatley‐Guy Jesse C. Schwartz Jordan K. Parks Bruce D. Johnson |
| author_facet | Kelsey E. Joyce M. Travis Byrd Courtney M. Wheatley‐Guy Jesse C. Schwartz Jordan K. Parks Bruce D. Johnson |
| author_sort | Kelsey E. Joyce |
| collection | DOAJ |
| description | Abstract Intermittent hypoxia has been used to enhance oxygen delivery in athletes and patients; however, it is unclear whether acute exposure is sufficient to elicit lasting physiologic adaptation(s). The purpose of this study was to evaluate physiologic response(s) to hypobaric‐hypoxic (HH) exercise. Nine participants (4 M/5F; 37.9 ± 12.7 yrs.; 174.3 ± 9.4 cm; 75.3 ± 15.9 kg; 24.4 ± 3.4 kg/m2) were exposed to progressively higher simulated altitudes and completed two HH submaximal exercise sessions (~30 min ea., ≥72 h apart) on a cycle ergometer at the first altitude that posed a significant challenge to them. Altitude was dependent on individual response as determined from heart rate (HR), peripheral oxygenation (SpO2), and the ratio of HR response to SpO2 (HR/SpO2). Statistical analyses included paired samples t‐test (p ≤ 0.05). No significant change in SpO2 (HH‐1: 85 ± 4% vs. HH‐2: 85 ± 4%, p = 0.684) was observed between sessions. However, there were significant decreases in: HR (HH‐1: 150 ± 18 bpm vs. HH‐2: 133 ± 27 bpm, p = 0.001) of 18 bpm (11%); HR/SpO2 (HH‐1: 1.76 ± 0.22 vs. HH‐2: 1.57 ± 0.33, p = 0.012); and RPE (HH‐1: 15 ± 2 vs. HH‐2: 11 ± 4, p = 0.017). While workload significantly increased (HH‐1: 89 ± 36 W vs. HH‐2: 105 ± 36 W, p = 0.024). Some participants had a threshold/challenging altitude, but from a single bout there is evidence of improved tolerance that can last over a week. Further investigation is required to replicate and understand possible mechanisms. |
| format | Article |
| id | doaj-art-14ed4e550a6f4eb3a02fcd8c5ec3c7e8 |
| institution | OA Journals |
| issn | 2051-817X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | Physiological Reports |
| spelling | doaj-art-14ed4e550a6f4eb3a02fcd8c5ec3c7e82025-08-20T02:12:38ZengWileyPhysiological Reports2051-817X2025-04-01137n/an/a10.14814/phy2.70195Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitudeKelsey E. Joyce0M. Travis Byrd1Courtney M. Wheatley‐Guy2Jesse C. Schwartz3Jordan K. Parks4Bruce D. Johnson5Human Integrative and Environmental Physiology Laboratory Department of Cardiovascular Diseases, Mayo Clinic Scottsdale Arizona USASchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKSchool of Sport, Exercise and Rehabilitation Sciences University of Birmingham Birmingham UKAbstract Intermittent hypoxia has been used to enhance oxygen delivery in athletes and patients; however, it is unclear whether acute exposure is sufficient to elicit lasting physiologic adaptation(s). The purpose of this study was to evaluate physiologic response(s) to hypobaric‐hypoxic (HH) exercise. Nine participants (4 M/5F; 37.9 ± 12.7 yrs.; 174.3 ± 9.4 cm; 75.3 ± 15.9 kg; 24.4 ± 3.4 kg/m2) were exposed to progressively higher simulated altitudes and completed two HH submaximal exercise sessions (~30 min ea., ≥72 h apart) on a cycle ergometer at the first altitude that posed a significant challenge to them. Altitude was dependent on individual response as determined from heart rate (HR), peripheral oxygenation (SpO2), and the ratio of HR response to SpO2 (HR/SpO2). Statistical analyses included paired samples t‐test (p ≤ 0.05). No significant change in SpO2 (HH‐1: 85 ± 4% vs. HH‐2: 85 ± 4%, p = 0.684) was observed between sessions. However, there were significant decreases in: HR (HH‐1: 150 ± 18 bpm vs. HH‐2: 133 ± 27 bpm, p = 0.001) of 18 bpm (11%); HR/SpO2 (HH‐1: 1.76 ± 0.22 vs. HH‐2: 1.57 ± 0.33, p = 0.012); and RPE (HH‐1: 15 ± 2 vs. HH‐2: 11 ± 4, p = 0.017). While workload significantly increased (HH‐1: 89 ± 36 W vs. HH‐2: 105 ± 36 W, p = 0.024). Some participants had a threshold/challenging altitude, but from a single bout there is evidence of improved tolerance that can last over a week. Further investigation is required to replicate and understand possible mechanisms.https://doi.org/10.14814/phy2.70195altitudehypoxiaintermittent hypoxic training |
| spellingShingle | Kelsey E. Joyce M. Travis Byrd Courtney M. Wheatley‐Guy Jesse C. Schwartz Jordan K. Parks Bruce D. Johnson Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude Physiological Reports altitude hypoxia intermittent hypoxic training |
| title | Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| title_full | Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| title_fullStr | Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| title_full_unstemmed | Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| title_short | Evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| title_sort | evidence for sustained physiological adaptation between consecutive exercise bouts at simulated altitude |
| topic | altitude hypoxia intermittent hypoxic training |
| url | https://doi.org/10.14814/phy2.70195 |
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