Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications
Abstract A crucial step in the engineering of bioactive materials from sugarcane by-products is understanding their physical, chemical, and biological characteristics, particularly their molecular composition and biological activities. This study aimed to characterize the physicochemical properties...
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Nature Portfolio
2025-06-01
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| Online Access: | https://doi.org/10.1038/s41598-025-03262-7 |
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| author | Andrea Molina-Cortés Fabian Tobar-Tosse Mauricio Quimbaya Gerardo Álvarez-Rivera Alejandro Cifuentes Andres Jaramillo-Botero |
| author_facet | Andrea Molina-Cortés Fabian Tobar-Tosse Mauricio Quimbaya Gerardo Álvarez-Rivera Alejandro Cifuentes Andres Jaramillo-Botero |
| author_sort | Andrea Molina-Cortés |
| collection | DOAJ |
| description | Abstract A crucial step in the engineering of bioactive materials from sugarcane by-products is understanding their physical, chemical, and biological characteristics, particularly their molecular composition and biological activities. This study aimed to characterize the physicochemical properties of methanolic and aqueous extracts from sugarcane molasses and vinasses, determine their antioxidant capacity, and identify key compounds of biological interest; specifically phenolic compounds (PCs) and heat-induced compounds (HICs). Through non-targeted analytical approaches, we identified a diverse range of PCs and HICs in the extracts. In vitro tests revealed significant antioxidant effects in both aqueous and methanolic fractions, with the methanolic extracts showing superior free radical scavenging capacity. This bioactivity was linked to PCs such as p-coumaric acid, 4-hydroxybenzoic acid, 4-hydroxybenzaldehyde, chlorogenic acid, and schaftoside, as well as HICs like 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP); 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF); 2,6-dimethoxyphenol; and 1,6-anhydro-β-D-glucopyranose. These findings underscore the potential of sugarcane molasses and vinasses as sources of bioactive compounds, which can be engineered into new materials with promising biological properties for health, pharmacological, and food industry applications. Furthermore, our research highlights the integration of bioengineering, material science, and sustainable practices within the sugarcane industry by promoting the valorization of by-products, contributing to resource efficiency and industrial innovation under circular economy principles. |
| format | Article |
| id | doaj-art-14e69b0bab424b0b9cd6ff1ae8edf345 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-14e69b0bab424b0b9cd6ff1ae8edf3452025-08-20T03:10:35ZengNature PortfolioScientific Reports2045-23222025-06-0115111610.1038/s41598-025-03262-7Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applicationsAndrea Molina-Cortés0Fabian Tobar-Tosse1Mauricio Quimbaya2Gerardo Álvarez-Rivera3Alejandro Cifuentes4Andres Jaramillo-Botero5Doctorate in Engineering and Applied Sciences, Faculty of Engineering and Sciences, Pontificia Universidad Javeriana CaliDoctorate in Engineering and Applied Sciences, Faculty of Engineering and Sciences, Pontificia Universidad Javeriana CaliDoctorate in Engineering and Applied Sciences, Faculty of Engineering and Sciences, Pontificia Universidad Javeriana CaliDepartment of Analytical Chemistry, Nutrition, and Food Science, CRETUS, Universidade de Santiago de CompostelaLaboratory of Foodomics, Institute of Food Science Research - CIAL, CSICDoctorate in Engineering and Applied Sciences, Faculty of Engineering and Sciences, Pontificia Universidad Javeriana CaliAbstract A crucial step in the engineering of bioactive materials from sugarcane by-products is understanding their physical, chemical, and biological characteristics, particularly their molecular composition and biological activities. This study aimed to characterize the physicochemical properties of methanolic and aqueous extracts from sugarcane molasses and vinasses, determine their antioxidant capacity, and identify key compounds of biological interest; specifically phenolic compounds (PCs) and heat-induced compounds (HICs). Through non-targeted analytical approaches, we identified a diverse range of PCs and HICs in the extracts. In vitro tests revealed significant antioxidant effects in both aqueous and methanolic fractions, with the methanolic extracts showing superior free radical scavenging capacity. This bioactivity was linked to PCs such as p-coumaric acid, 4-hydroxybenzoic acid, 4-hydroxybenzaldehyde, chlorogenic acid, and schaftoside, as well as HICs like 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP); 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF); 2,6-dimethoxyphenol; and 1,6-anhydro-β-D-glucopyranose. These findings underscore the potential of sugarcane molasses and vinasses as sources of bioactive compounds, which can be engineered into new materials with promising biological properties for health, pharmacological, and food industry applications. Furthermore, our research highlights the integration of bioengineering, material science, and sustainable practices within the sugarcane industry by promoting the valorization of by-products, contributing to resource efficiency and industrial innovation under circular economy principles.https://doi.org/10.1038/s41598-025-03262-7Molasses and vinassesPhenolic compoundsMaillard reaction productsBioactivityAntioxidant capacitySustainable innovation |
| spellingShingle | Andrea Molina-Cortés Fabian Tobar-Tosse Mauricio Quimbaya Gerardo Álvarez-Rivera Alejandro Cifuentes Andres Jaramillo-Botero Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications Scientific Reports Molasses and vinasses Phenolic compounds Maillard reaction products Bioactivity Antioxidant capacity Sustainable innovation |
| title | Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications |
| title_full | Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications |
| title_fullStr | Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications |
| title_full_unstemmed | Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications |
| title_short | Study of two sugarcane by-products as source of secondary metabolites and heat-induced compounds with potential bioactive applications |
| title_sort | study of two sugarcane by products as source of secondary metabolites and heat induced compounds with potential bioactive applications |
| topic | Molasses and vinasses Phenolic compounds Maillard reaction products Bioactivity Antioxidant capacity Sustainable innovation |
| url | https://doi.org/10.1038/s41598-025-03262-7 |
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