EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA
Abstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in health...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
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| Online Access: | https://www.mimmun.ru/mimmun/article/view/346 |
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| author | V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov |
| author_facet | V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov |
| author_sort | V. A. Mikhailova |
| collection | DOAJ |
| description | Abstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in healthy pregnancy and in pre-eclampsia. The amounts of CD4+T-lymphocytes expressing CD184, CD119, CD192, CD197, β7 integrin, CD29, CD49d, CD11b were elevated in healthy pregnant women, as compared with non-pregnant women. The amounts of CD4+T-lymphocytes expressing CD49d, CD44, CD47, as well as intensity of CD47, CD29, CD49d, CD44, Integrin β7, CD54 expression proved to be decreased in cases of preeclampsia when compared with healthy pregnancy. This work was supported by grants ГК N 02.740.11.0711 from Russian Ministry of Education and Science, and Presidential grants НШ-3594.2010.7, МД-150.2011.7. |
| format | Article |
| id | doaj-art-14e511741f9940cc8c76ebe0d3dfb5cd |
| institution | Kabale University |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-14e511741f9940cc8c76ebe0d3dfb5cd2025-08-20T04:00:09ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114319520010.15789/1563-0625-2012-3-195-200343EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIAV. A. Mikhailova0Y. S. Onokhina1O. M. Ovchinnikova2M. I. Mirashvili3M. S. Zainulina4S. A. Sel’kov5D. I. Sokolov6Учреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургУчреждение Российской академии медицинских наук «Научно-Исследовательский институт акушерства и гинекологии им. Д.О. Отта СЗО РАМН», Санкт-ПетербургAbstract. In course of physiological pregnancy, peripheral blood CD4+T-lymphocytes normally migrate to the uterine decidual tissue. Hence, this study aimed to compare expression profiles of adhesion molecules and chemokine receptors on the surface of CD4+T-lymphocytes from peripheral blood in healthy pregnancy and in pre-eclampsia. The amounts of CD4+T-lymphocytes expressing CD184, CD119, CD192, CD197, β7 integrin, CD29, CD49d, CD11b were elevated in healthy pregnant women, as compared with non-pregnant women. The amounts of CD4+T-lymphocytes expressing CD49d, CD44, CD47, as well as intensity of CD47, CD29, CD49d, CD44, Integrin β7, CD54 expression proved to be decreased in cases of preeclampsia when compared with healthy pregnancy. This work was supported by grants ГК N 02.740.11.0711 from Russian Ministry of Education and Science, and Presidential grants НШ-3594.2010.7, МД-150.2011.7.https://www.mimmun.ru/mimmun/article/view/346cd4+т-lymphocytespregnancypre-eclampsiacd184cd47 |
| spellingShingle | V. A. Mikhailova Y. S. Onokhina O. M. Ovchinnikova M. I. Mirashvili M. S. Zainulina S. A. Sel’kov D. I. Sokolov EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA Медицинская иммунология cd4+т-lymphocytes pregnancy pre-eclampsia cd184 cd47 |
| title | EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA |
| title_full | EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA |
| title_fullStr | EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA |
| title_full_unstemmed | EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA |
| title_short | EXPRESSION OF SURFACE MARKERS ON CD4+T-LYMPHOCYTES IN NORMAL PREGNANCY AND PRE-ECLAMPSIA |
| title_sort | expression of surface markers on cd4 t lymphocytes in normal pregnancy and pre eclampsia |
| topic | cd4+т-lymphocytes pregnancy pre-eclampsia cd184 cd47 |
| url | https://www.mimmun.ru/mimmun/article/view/346 |
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