Research progress on ocular rosacea
Rosacea is a chronic inflammatory disease affecting the central face, with approximately 6% to 72% of patients experiencing ocular involvement. Ocular rosacea shares a similar pathogenesis with cutaneous rosacea, involving immune responses, neurovascular dysfunction, and alterations in the ocular mi...
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-05-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.05.011 |
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| _version_ | 1849707567139258368 |
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| author | WANG Xiaoyan ZHANG Yingpeng |
| author_facet | WANG Xiaoyan ZHANG Yingpeng |
| author_sort | WANG Xiaoyan |
| collection | DOAJ |
| description | Rosacea is a chronic inflammatory disease affecting the central face, with approximately 6% to 72% of patients experiencing ocular involvement. Ocular rosacea shares a similar pathogenesis with cutaneous rosacea, involving immune responses, neurovascular dysfunction, and alterations in the ocular microbiome, which contribute to inflammation and meibomian gland dysfunction. Common ocular manifestations include conjunctivitis, blepharitis, keratitis, and telangiectasia of the lid margin. However, these clinical features are nonspecific making diagnosis challenging, especially blepharokeratoconjunctivitis in children, where the absence of skin symptoms often leads to misdiagnosis or missed diagnosis. Current treatment emphasizes a gradual and stepwise approach, with most management being empirical and symptomatic. Further exploration of effective, targeted treatment options is necessary. This article reviews the pathogenesis, clinical manifestations, diagnosis, and treatment advancements of ocular rosacea to enhance clinicians' understanding of this disease. |
| format | Article |
| id | doaj-art-14e16edeadf149ec99613f417f0cba12 |
| institution | DOAJ |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-05-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-14e16edeadf149ec99613f417f0cba122025-08-20T03:15:54Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-05-0132537137610.3969/j.issn.1674-8468.2025.05.011Research progress on ocular rosaceaWANG Xiaoyan0ZHANG Yingpeng1Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaSecond Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaRosacea is a chronic inflammatory disease affecting the central face, with approximately 6% to 72% of patients experiencing ocular involvement. Ocular rosacea shares a similar pathogenesis with cutaneous rosacea, involving immune responses, neurovascular dysfunction, and alterations in the ocular microbiome, which contribute to inflammation and meibomian gland dysfunction. Common ocular manifestations include conjunctivitis, blepharitis, keratitis, and telangiectasia of the lid margin. However, these clinical features are nonspecific making diagnosis challenging, especially blepharokeratoconjunctivitis in children, where the absence of skin symptoms often leads to misdiagnosis or missed diagnosis. Current treatment emphasizes a gradual and stepwise approach, with most management being empirical and symptomatic. Further exploration of effective, targeted treatment options is necessary. This article reviews the pathogenesis, clinical manifestations, diagnosis, and treatment advancements of ocular rosacea to enhance clinicians' understanding of this disease.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.05.011ocular rosaceaadaptive immune systeminnate immune systemtlr-4 |
| spellingShingle | WANG Xiaoyan ZHANG Yingpeng Research progress on ocular rosacea Pifu-xingbing zhenliaoxue zazhi ocular rosacea adaptive immune system innate immune system tlr-4 |
| title | Research progress on ocular rosacea |
| title_full | Research progress on ocular rosacea |
| title_fullStr | Research progress on ocular rosacea |
| title_full_unstemmed | Research progress on ocular rosacea |
| title_short | Research progress on ocular rosacea |
| title_sort | research progress on ocular rosacea |
| topic | ocular rosacea adaptive immune system innate immune system tlr-4 |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.05.011 |
| work_keys_str_mv | AT wangxiaoyan researchprogressonocularrosacea AT zhangyingpeng researchprogressonocularrosacea |