Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity
This study includs the synthesis of some new Amic acid and Imides, starting from the esters [S1] of Terephthalic acid which then converted to its hydrazide [S2] then to amic acid derivatives [S3-S7] and finally with imides [S8-S12]. Preparing of ester [S1] by usual esterification of terephthalic ac...
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| Language: | English |
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Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/811 |
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| author | Salwa Abd Al-Satar Jabbar |
| author_facet | Salwa Abd Al-Satar Jabbar |
| author_sort | Salwa Abd Al-Satar Jabbar |
| collection | DOAJ |
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This study includs the synthesis of some new Amic acid and Imides,
starting from the esters [S1] of Terephthalic acid which then converted to
its hydrazide [S2] then to amic acid derivatives [S3-S7] and finally with
imides [S8-S12]. Preparing of ester [S1] by usual esterification of
terephthalic acid with absolute ethanol in acidic medium, then has
converted to its hydrazide [S2] by reacting it with hydrazine hydrate. The
amic acid derivatives [S3-S7] have been synthesized by the reaction of
hydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitro
phthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride,
tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] were
also synthesized by cyclization of amic acids derivatives using acetic
acid anhydride and anhydrous sodium acetate. The synthesized
compounds were identified by spectral methods UV, FT-IR and H1-
NMR beside melting point and the purity was determined using (TLC)
and some of its physical properties were measured. Some of these
compounds were tested against four strains of bacteria (E. coli, P.
ariginosa, S. aurous and S. pyogenes)
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| format | Article |
| id | doaj-art-14d8121f3ebf43be97de3c8f99e06edc |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-14d8121f3ebf43be97de3c8f99e06edc2025-08-20T03:50:25ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-01-0123910.25130/tjps.v23i9.811Synthesis and Characterization of some New Amic acid and Imides and study the Biological ActivitySalwa Abd Al-Satar Jabbar This study includs the synthesis of some new Amic acid and Imides, starting from the esters [S1] of Terephthalic acid which then converted to its hydrazide [S2] then to amic acid derivatives [S3-S7] and finally with imides [S8-S12]. Preparing of ester [S1] by usual esterification of terephthalic acid with absolute ethanol in acidic medium, then has converted to its hydrazide [S2] by reacting it with hydrazine hydrate. The amic acid derivatives [S3-S7] have been synthesized by the reaction of hydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitro phthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride, tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] were also synthesized by cyclization of amic acids derivatives using acetic acid anhydride and anhydrous sodium acetate. The synthesized compounds were identified by spectral methods UV, FT-IR and H1- NMR beside melting point and the purity was determined using (TLC) and some of its physical properties were measured. Some of these compounds were tested against four strains of bacteria (E. coli, P. ariginosa, S. aurous and S. pyogenes) https://tjpsj.org/index.php/tjps/article/view/811Terephthalic acidDerivatives amic acidDerivatives imides |
| spellingShingle | Salwa Abd Al-Satar Jabbar Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity Tikrit Journal of Pure Science Terephthalic acid Derivatives amic acid Derivatives imides |
| title | Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity |
| title_full | Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity |
| title_fullStr | Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity |
| title_full_unstemmed | Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity |
| title_short | Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity |
| title_sort | synthesis and characterization of some new amic acid and imides and study the biological activity |
| topic | Terephthalic acid Derivatives amic acid Derivatives imides |
| url | https://tjpsj.org/index.php/tjps/article/view/811 |
| work_keys_str_mv | AT salwaabdalsatarjabbar synthesisandcharacterizationofsomenewamicacidandimidesandstudythebiologicalactivity |