The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types.

The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types.

Stem cells have lower facultative heterochromatin as defined by trimethylation of histone H3 lysine 27 (H3K27me3) compared to differentiated cells. However, the mechanisms underlying these differential H3K27me3 levels remain elusive. Because H3K27me3 levels are diluted 2-fold in every round of repli...

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Main Authors: Abby Trouth, Kameswaran Ravichandran, Philip R Gafken, Sara Martire, Gabriel E Boyle, Giovana M B Veronezi, Van La, Stephanie J Namciu, Laura A Banaszynski, Jay F Sarthy, Srinivas Ramachandran
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003119
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