The Unregulated Opioid: Neurologic and Electrolyte Imbalance From Long-Term Kratom Use

Mitragyna speciosa, commonly known as kratom, is a Southeast Asian herb gaining popularity as an alternative to opioids for chronic pain and opioid withdrawal treatment. The U.S. Food and Drug Administration classifies it as a “new dietary ingredient” with the potential to damage the kidneys, liver,...

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Bibliographic Details
Main Authors: Talal Alomar, Josiah Bardwell, Deepti Boddupalli
Format: Article
Language:English
Published: American College of Physicians 2025-01-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2024.0805
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Summary:Mitragyna speciosa, commonly known as kratom, is a Southeast Asian herb gaining popularity as an alternative to opioids for chronic pain and opioid withdrawal treatment. The U.S. Food and Drug Administration classifies it as a “new dietary ingredient” with the potential to damage the kidneys, liver, and heart. Despite this, kratom is widely available in drug stores and online. We present a case of a patient with long-term daily use of kratom who exhibited altered mental status and focal neurologic deficits with hyponatremia 1 week after abruptly discontinuing kratom use. This case underscores the necessity of obtaining a comprehensive history of all regularly consumed medications and supplements, whether prescribed or otherwise.
ISSN:2767-7664