Recurrent transient visual loss in secretory carcinoid tumor
Purpose: We describe a case of a 68-year-old woman who had a biopsy-proven carcinoid of the lung and transient episodes of unilateral and bilateral vision loss presumed to be the result to intermittent serum elevations of vasoactive peptides secondary to an occult carcinoid. Observations: A 68-year-...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993625000428 |
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| author | Vivian Paraskevi Douglas Shahin Owji Mohammad Pakravan Chaow Charoenkijkajorn Noor A.R. Laylani Pamela Davila-Siliezar Yingchao Piao Andrew G. Lee |
| author_facet | Vivian Paraskevi Douglas Shahin Owji Mohammad Pakravan Chaow Charoenkijkajorn Noor A.R. Laylani Pamela Davila-Siliezar Yingchao Piao Andrew G. Lee |
| author_sort | Vivian Paraskevi Douglas |
| collection | DOAJ |
| description | Purpose: We describe a case of a 68-year-old woman who had a biopsy-proven carcinoid of the lung and transient episodes of unilateral and bilateral vision loss presumed to be the result to intermittent serum elevations of vasoactive peptides secondary to an occult carcinoid. Observations: A 68-year-old female with history of carcinoid tumor of the lung presented with multiple recurrent and alternating unilateral and bilateral transient vision loss (TVL) which were increasing in frequency over a period of one month. Ophthalmologic examination was unremarkable. Further investigations were significant for elevated levels of serum chromogranin A. Positron emission tomography (PET) showed no recurrent or metastatic carcinoid tumor until after 11 months of persisting symptoms along with increased serum chromogranin A levels where three carcinoid tumorlets were detected in the left lower pulmonary lobe. Conclusions and importance: Clinicians should be aware that TVL can be a manifestation of the vasoactive secretory products in patients with history of carcinoid tumor. |
| format | Article |
| id | doaj-art-14ca7571a1e7495aa2df1d4f164ce430 |
| institution | OA Journals |
| issn | 2451-9936 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj-art-14ca7571a1e7495aa2df1d4f164ce4302025-08-20T02:25:12ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362025-06-013810228910.1016/j.ajoc.2025.102289Recurrent transient visual loss in secretory carcinoid tumorVivian Paraskevi Douglas0Shahin Owji1Mohammad Pakravan2Chaow Charoenkijkajorn3Noor A.R. Laylani4Pamela Davila-Siliezar5Yingchao Piao6Andrew G. Lee7Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USADepartment of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USADepartment of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USADepartment of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USADepartment of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USADepartment of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USADepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USADepartment of Ophthalmology, University of Texas Medical Branch, Galveston, TX, USA; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, USA; University of Texas MD Anderson Cancer Center, Houston, TX, USA; Texas A and M College of Medicine, Bryan, TX, USA; Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Corresponding author. Department of Ophthalmology - Blanton Eye Institute, Houston Methodist Hospital 6560 Fannin St. Ste 450 Houston, TX 77030, USA.Purpose: We describe a case of a 68-year-old woman who had a biopsy-proven carcinoid of the lung and transient episodes of unilateral and bilateral vision loss presumed to be the result to intermittent serum elevations of vasoactive peptides secondary to an occult carcinoid. Observations: A 68-year-old female with history of carcinoid tumor of the lung presented with multiple recurrent and alternating unilateral and bilateral transient vision loss (TVL) which were increasing in frequency over a period of one month. Ophthalmologic examination was unremarkable. Further investigations were significant for elevated levels of serum chromogranin A. Positron emission tomography (PET) showed no recurrent or metastatic carcinoid tumor until after 11 months of persisting symptoms along with increased serum chromogranin A levels where three carcinoid tumorlets were detected in the left lower pulmonary lobe. Conclusions and importance: Clinicians should be aware that TVL can be a manifestation of the vasoactive secretory products in patients with history of carcinoid tumor.http://www.sciencedirect.com/science/article/pii/S2451993625000428Carcinoid syndromeTransient visual lossTVL |
| spellingShingle | Vivian Paraskevi Douglas Shahin Owji Mohammad Pakravan Chaow Charoenkijkajorn Noor A.R. Laylani Pamela Davila-Siliezar Yingchao Piao Andrew G. Lee Recurrent transient visual loss in secretory carcinoid tumor American Journal of Ophthalmology Case Reports Carcinoid syndrome Transient visual loss TVL |
| title | Recurrent transient visual loss in secretory carcinoid tumor |
| title_full | Recurrent transient visual loss in secretory carcinoid tumor |
| title_fullStr | Recurrent transient visual loss in secretory carcinoid tumor |
| title_full_unstemmed | Recurrent transient visual loss in secretory carcinoid tumor |
| title_short | Recurrent transient visual loss in secretory carcinoid tumor |
| title_sort | recurrent transient visual loss in secretory carcinoid tumor |
| topic | Carcinoid syndrome Transient visual loss TVL |
| url | http://www.sciencedirect.com/science/article/pii/S2451993625000428 |
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