CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation

CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation

Abstract Background Aging is the greatest risk factor for breast cancer, and although epithelial cells are the source of carcinomas, epithelial changes alone do not fully explain cancer susceptibility. Fibroblasts and macrophages are key stromal constituents around the cells of origin for cancer in...

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Bibliographic Details
Main Authors: Eric G. Carlson, Jennifer C. Lopez, Yukiko Yamaguchi, Jackson Gibson, Saul J. Priceman, Mark A. LaBarge
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Breast Cancer Research
Subjects:
Intralobular fibroblasts
Aging
BRCA1
Macrophages
Immunosuppressive
Online Access:https://doi.org/10.1186/s13058-025-02040-7
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