Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients
Introduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4 + EBI3 + T cells in VMC patients were detected to investigate the significance of changes in t...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-02-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/Significant-reduction-of-peripheral-blood-interleukin-35-and-CD4-EBI3-T-cells-which-are-negatively-correlated-with-an-increase-in-the-plasma-IL-17-and-cTnI-level-in-viral-myocarditis-patients,10,29487,1,1.html |
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| author | Han Ouyang Li Xiang Jianchang Chen Weiting Xu Yang Jiao Huaying Shen |
| author_facet | Han Ouyang Li Xiang Jianchang Chen Weiting Xu Yang Jiao Huaying Shen |
| author_sort | Han Ouyang |
| collection | DOAJ |
| description | Introduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4 + EBI3 + T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease.
Material and methods: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4 + EBI3 + T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups.
Results : Plasma IL-35 level and the percentage of CD4 + EBI3 + T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4 + EBI3 + T cells also showed a negative correlation with the levels of cTnI and IL-17.
Conclusions : The plasma IL-35 level and the percentage of CD4 + EBI3 + T cells in VMC patients was reduced, and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4 + EBI3 + T might play important roles in the progression of VMC and could be used as indictors of the disease. |
| format | Article |
| id | doaj-art-14c98d559a8143ec8cf342f9a4a35c8c |
| institution | OA Journals |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-14c98d559a8143ec8cf342f9a4a35c8c2025-08-20T02:09:25ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242017-02-01421919610.5114/ceji.2016.6589229487Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patientsHan OuyangLi XiangJianchang ChenWeiting XuYang JiaoHuaying ShenIntroduction: Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4 + EBI3 + T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease. Material and methods: ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4 + EBI3 + T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups. Results : Plasma IL-35 level and the percentage of CD4 + EBI3 + T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4 + EBI3 + T cells also showed a negative correlation with the levels of cTnI and IL-17. Conclusions : The plasma IL-35 level and the percentage of CD4 + EBI3 + T cells in VMC patients was reduced, and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4 + EBI3 + T might play important roles in the progression of VMC and could be used as indictors of the disease.https://www.termedia.pl/Significant-reduction-of-peripheral-blood-interleukin-35-and-CD4-EBI3-T-cells-which-are-negatively-correlated-with-an-increase-in-the-plasma-IL-17-and-cTnI-level-in-viral-myocarditis-patients,10,29487,1,1.html<i>viral disease myocarditis interleukin-35 EBI3</i> |
| spellingShingle | Han Ouyang Li Xiang Jianchang Chen Weiting Xu Yang Jiao Huaying Shen Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients Central European Journal of Immunology <i>viral disease myocarditis interleukin-35 EBI3</i> |
| title | Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients |
| title_full | Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients |
| title_fullStr | Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients |
| title_full_unstemmed | Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients |
| title_short | Significant reduction of peripheral blood interleukin-35 and CD4+EBI3+ T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients |
| title_sort | significant reduction of peripheral blood interleukin 35 and cd4 ebi3 t cells which are negatively correlated with an increase in the plasma il 17 and ctni level in viral myocarditis patients |
| topic | <i>viral disease myocarditis interleukin-35 EBI3</i> |
| url | https://www.termedia.pl/Significant-reduction-of-peripheral-blood-interleukin-35-and-CD4-EBI3-T-cells-which-are-negatively-correlated-with-an-increase-in-the-plasma-IL-17-and-cTnI-level-in-viral-myocarditis-patients,10,29487,1,1.html |
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