Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing
Wound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. Mesenchymal stem cells participate in the recruitment site, mainly by releasing secr...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/1285087 |
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| author | Jianghong Huang Jun Zhang Jianyi Xiong Shuqing Sun Jiang Xia Lei Yang Yujie Liang |
| author_facet | Jianghong Huang Jun Zhang Jianyi Xiong Shuqing Sun Jiang Xia Lei Yang Yujie Liang |
| author_sort | Jianghong Huang |
| collection | DOAJ |
| description | Wound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. Mesenchymal stem cells participate in the recruitment site, mainly by releasing secretory factors and matrix proteins to promote wound healing. Stem cell-derived nanovesicles (CDNs), including microvesicles, exosomes, and exosome mimetics, contain most of the biologically active substances of their parent cells and have similar effects. CDNs can shuttle various proteins, messenger RNAs, and microRNAs to regulate the activity of receptor cells, and they play important roles in skin wound healing. This article reviews recent research progress on CDNs for wound repair. We summarize current knowledge on how CDNs regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process. This review can help researchers explore new treatment strategies to enhance the therapeutic efficacy of CDNs, which have a promising future as naturally cell-free therapies. |
| format | Article |
| id | doaj-art-14c7331f3204487fab1b8762c1e73bf6 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-14c7331f3204487fab1b8762c1e73bf62025-02-03T01:12:54ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/12850871285087Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound HealingJianghong Huang0Jun Zhang1Jianyi Xiong2Shuqing Sun3Jiang Xia4Lei Yang5Yujie Liang6Department of Orthopedics, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University, Health Science Center), Shenzhen 518035, ChinaTsinghua University Shenzhen International Graduate School, Class 9 of 2020 Engineering Ph.D., Shenzhen 518055, ChinaDepartment of Orthopedics, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University, Health Science Center), Shenzhen 518035, ChinaTsinghua University Shenzhen International Graduate School, Institute of Biomedicine and Health Engineering, Shenzhen 518055, ChinaDepartment of Chemistry, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, ChinaDepartment of Orthopedics, Shenzhen Second People’s Hospital (First Affiliated Hospital of Shenzhen University, Health Science Center), Shenzhen 518035, ChinaDepartment of Child and Adolescent Psychiatry, Shenzhen Kangning Hospital, Shenzhen Mental Health Center, Shenzhen Key Laboratory for Psychological Healthcare & Shenzhen Institute of Mental Health, Shenzhen 518020, ChinaWound healing and regeneration are a dynamic and complex process that requires a collaborative effort between growth factors, epidermal cells, dermal cells, extracellular matrix, and vessels local to the wound area. Mesenchymal stem cells participate in the recruitment site, mainly by releasing secretory factors and matrix proteins to promote wound healing. Stem cell-derived nanovesicles (CDNs), including microvesicles, exosomes, and exosome mimetics, contain most of the biologically active substances of their parent cells and have similar effects. CDNs can shuttle various proteins, messenger RNAs, and microRNAs to regulate the activity of receptor cells, and they play important roles in skin wound healing. This article reviews recent research progress on CDNs for wound repair. We summarize current knowledge on how CDNs regulate immunity, fibroblast activity, angiogenesis, and scar formation in the wound healing process. This review can help researchers explore new treatment strategies to enhance the therapeutic efficacy of CDNs, which have a promising future as naturally cell-free therapies.http://dx.doi.org/10.1155/2021/1285087 |
| spellingShingle | Jianghong Huang Jun Zhang Jianyi Xiong Shuqing Sun Jiang Xia Lei Yang Yujie Liang Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing Stem Cells International |
| title | Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing |
| title_full | Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing |
| title_fullStr | Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing |
| title_full_unstemmed | Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing |
| title_short | Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing |
| title_sort | stem cell derived nanovesicles a novel cell free therapy for wound healing |
| url | http://dx.doi.org/10.1155/2021/1285087 |
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