The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

Abstract Loss of PTEN expression, via homozygous or hemizygous deletion, is common in PIK3CA mutant ER + BC tumors. We assessed reduction of PTEN protein expression on AKT inhibitor capivasertib efficacy in PIK3CA altered tumors. In PIK3CA altered, PTEN protein high models, PI3Kα and AKT inhibition...

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Main Authors: Valentina Cutano, Ming Li Chia, Eleanor M. Wigmore, Lorna Hopcroft, Stuart C. Williamson, Amanda L. Christie, Brandon Willis, James Kerr, Jenny Ashforth, Rhys Fox, Sophie D’Arcy, Lauren Bradshaw, Catherine Blaker, Cath Eberlein, Lambert Montava-Garriga, Elza C. de Bruin, Susan E. Critchlow, Kevin M. Brindle, Simon T. Barry, Susana Ros
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00752-9
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