A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients
Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/375427 |
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| author | Anas Khaleel Mei-Shin Wu Henry Sung-Ching Wong Yu-Wen Hsu Yii-Her Chou Hsiang-Yin Chen |
| author_facet | Anas Khaleel Mei-Shin Wu Henry Sung-Ching Wong Yu-Wen Hsu Yii-Her Chou Hsiang-Yin Chen |
| author_sort | Anas Khaleel |
| collection | DOAJ |
| description | Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calcium homeostasis. However, whether genetic polymorphisms of TRPV5 are associated with kidney stone multiplicity or recurrence is unclear. In this study, 365 Taiwanese kidney-stone patients were recruited. Both biochemical data and DNA samples were collected. Genotyping was performed by a TaqMan allelic discrimination assay. We found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype (p=0.0271). In summary, despite the complexity of nephrolithiasis and the potential association of numerous calcium homeostatic absorption/reabsorption factors, TRPV5 plays an important role in the pathogenesis of calcium nephrolithiasis. |
| format | Article |
| id | doaj-art-14c11bb1ab9146eaa80fa5c18c9c5e36 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-14c11bb1ab9146eaa80fa5c18c9c5e362025-08-20T03:54:29ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/375427375427A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis PatientsAnas Khaleel0Mei-Shin Wu1Henry Sung-Ching Wong2Yu-Wen Hsu3Yii-Her Chou4Hsiang-Yin Chen5Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanDepartment of Urology, College of Medicine, Kaohsiung Medical University, Kaohsiung 80756, TaiwanDepartment of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanNephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calcium homeostasis. However, whether genetic polymorphisms of TRPV5 are associated with kidney stone multiplicity or recurrence is unclear. In this study, 365 Taiwanese kidney-stone patients were recruited. Both biochemical data and DNA samples were collected. Genotyping was performed by a TaqMan allelic discrimination assay. We found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype (p=0.0271). In summary, despite the complexity of nephrolithiasis and the potential association of numerous calcium homeostatic absorption/reabsorption factors, TRPV5 plays an important role in the pathogenesis of calcium nephrolithiasis.http://dx.doi.org/10.1155/2015/375427 |
| spellingShingle | Anas Khaleel Mei-Shin Wu Henry Sung-Ching Wong Yu-Wen Hsu Yii-Her Chou Hsiang-Yin Chen A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients Mediators of Inflammation |
| title | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients |
| title_full | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients |
| title_fullStr | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients |
| title_full_unstemmed | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients |
| title_short | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients |
| title_sort | single nucleotide polymorphism rs4236480 in trpv5 calcium channel gene is associated with stone multiplicity in calcium nephrolithiasis patients |
| url | http://dx.doi.org/10.1155/2015/375427 |
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