Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study

Background. Neuropathic pain after brachial plexus avulsion remained prevalent and intractable currently. However, the neuroimaging study about neural mechanisms or etiology was limited and blurred. Objective. This study is aimed at investigating the effect of electroacupuncture on effective connect...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhen-Zhen Ma, Ye-Chen Lu, Jia-Jia Wu, Xiang-Xin Xing, Xu-Yun Hua, Jian-Guang Xu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2020/5052840
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832547758128496640
author Zhen-Zhen Ma
Ye-Chen Lu
Jia-Jia Wu
Xiang-Xin Xing
Xu-Yun Hua
Jian-Guang Xu
author_facet Zhen-Zhen Ma
Ye-Chen Lu
Jia-Jia Wu
Xiang-Xin Xing
Xu-Yun Hua
Jian-Guang Xu
author_sort Zhen-Zhen Ma
collection DOAJ
description Background. Neuropathic pain after brachial plexus avulsion remained prevalent and intractable currently. However, the neuroimaging study about neural mechanisms or etiology was limited and blurred. Objective. This study is aimed at investigating the effect of electroacupuncture on effective connectivity and neural response in corticolimbic circuitries during implicit processing of nociceptive stimulus in rats with brachial plexus pain. Methods. An fMRI scan was performed in a total of 16 rats with brachial plexus pain, which was equally distributed into the model group and the electroacupuncture group. The analysis of task-dependent data determined pain-related activation in each group. Based on those results, several regions including AMY, S1, and h were recruited as ROI in dynamic causal modeling (DCM) analysis comparing evidence for different neuronal hypotheses describing the propagation of noxious stimuli in regions of interest and horizontal comparison of effective connections between the model and electroacupuncture groups. Results. In both groups, DCM revealed that noxious stimuli were most likely driven by the somatosensory cortex, with bidirectional propagation with the hypothalamus and amygdala and the interactions in them. Also, the 3-month intervention of acupuncture reduced effective connections of h-S1 and AMY-S1. Conclusions. We showed an evidence that a full connection model within the brain network of brachial plexus pain and electroacupuncture intervention reduces effective connectivity from h and AMY to S1. Our study for the first time explored the relationship of involved brain regions with dynamic causal modeling. It provided novel evidence for the feature of the organization of the cortical-limbic network and the alteration caused by acupuncture.
format Article
id doaj-art-14bee35db4e44167ac237387a0616e85
institution Kabale University
issn 2090-5904
1687-5443
language English
publishDate 2020-01-01
publisher Wiley
record_format Article
series Neural Plasticity
spelling doaj-art-14bee35db4e44167ac237387a0616e852025-02-03T06:43:24ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/50528405052840Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling StudyZhen-Zhen Ma0Ye-Chen Lu1Jia-Jia Wu2Xiang-Xin Xing3Xu-Yun Hua4Jian-Guang Xu5Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaCenter of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaBackground. Neuropathic pain after brachial plexus avulsion remained prevalent and intractable currently. However, the neuroimaging study about neural mechanisms or etiology was limited and blurred. Objective. This study is aimed at investigating the effect of electroacupuncture on effective connectivity and neural response in corticolimbic circuitries during implicit processing of nociceptive stimulus in rats with brachial plexus pain. Methods. An fMRI scan was performed in a total of 16 rats with brachial plexus pain, which was equally distributed into the model group and the electroacupuncture group. The analysis of task-dependent data determined pain-related activation in each group. Based on those results, several regions including AMY, S1, and h were recruited as ROI in dynamic causal modeling (DCM) analysis comparing evidence for different neuronal hypotheses describing the propagation of noxious stimuli in regions of interest and horizontal comparison of effective connections between the model and electroacupuncture groups. Results. In both groups, DCM revealed that noxious stimuli were most likely driven by the somatosensory cortex, with bidirectional propagation with the hypothalamus and amygdala and the interactions in them. Also, the 3-month intervention of acupuncture reduced effective connections of h-S1 and AMY-S1. Conclusions. We showed an evidence that a full connection model within the brain network of brachial plexus pain and electroacupuncture intervention reduces effective connectivity from h and AMY to S1. Our study for the first time explored the relationship of involved brain regions with dynamic causal modeling. It provided novel evidence for the feature of the organization of the cortical-limbic network and the alteration caused by acupuncture.http://dx.doi.org/10.1155/2020/5052840
spellingShingle Zhen-Zhen Ma
Ye-Chen Lu
Jia-Jia Wu
Xiang-Xin Xing
Xu-Yun Hua
Jian-Guang Xu
Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
Neural Plasticity
title Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
title_full Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
title_fullStr Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
title_full_unstemmed Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
title_short Acupuncture Induces Reduction in Limbic-Cortical Feedback of a Neuralgia Rat Model: A Dynamic Causal Modeling Study
title_sort acupuncture induces reduction in limbic cortical feedback of a neuralgia rat model a dynamic causal modeling study
url http://dx.doi.org/10.1155/2020/5052840
work_keys_str_mv AT zhenzhenma acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy
AT yechenlu acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy
AT jiajiawu acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy
AT xiangxinxing acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy
AT xuyunhua acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy
AT jianguangxu acupunctureinducesreductioninlimbiccorticalfeedbackofaneuralgiaratmodeladynamiccausalmodelingstudy