The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage
Background: The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage. Methods: This case series study evaluated the serum sST2 and cfDNA levels of 6...
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Society of Medical Biochemists of Serbia, Belgrade
2025-01-01
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| Series: | Journal of Medical Biochemistry |
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| author | Zhao Tingting Liu Ye Jia Haoran Wang Dexing Du Meng Wang Weiwei |
| author_facet | Zhao Tingting Liu Ye Jia Haoran Wang Dexing Du Meng Wang Weiwei |
| author_sort | Zhao Tingting |
| collection | DOAJ |
| description | Background: The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage. Methods: This case series study evaluated the serum sST2 and cfDNA levels of 60 children with severe pneumonia complicated by myocardial damage, assessing clinical data, biomarker levels, and cardiac function. Results: We analyzed data from a cohort of 60 patients with a mean age of 4.47±1.88 years and a male: female ratio of 28:32. At baseline, patients had elevated levels of serum biomarkers, including sST2 and cfDNA, which were associated with cardiac function parameters and clinical outcomes. After 6 months, patients showed significant correlations between sST2, cfDNA, and cardiac function parameters, including left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd), and E/A ratio. Multivariate analysis revealed that higher levels of sST2 and cfDNA were associated with increased LVEDd, LVESd, and E/A ratio, as well as a lower likelihood of improvement and a higher likelihood of 6-month readmission. Conclusions: These findings suggest that sST2 and cfDNA may be useful biomarkers for predicting cardiac function and outcomes in this patient population. |
| format | Article |
| id | doaj-art-14bb181432e947889f447b382187d4fd |
| institution | DOAJ |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
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| series | Journal of Medical Biochemistry |
| spelling | doaj-art-14bb181432e947889f447b382187d4fd2025-08-20T02:54:50ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662025-01-0144226426810.5937/jomb0-511971452-82582502264ZThe significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damageZhao Tingting0Liu Ye1Jia Haoran2Wang Dexing3Du Meng4Wang Weiwei5Baoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology, Baoding, ChinaBaoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology, Baoding, ChinaBaoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology, Baoding, ChinaBaoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Pediatrics, Baoding, ChinaBaoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Neonatology, Baoding, ChinaBaoding Hospital of Beijing Children's Hospital Affiliated to Capital Medical University, Pediatrics, Baoding, ChinaBackground: The paper aimed to explore the significance of serum soluble ST2 (sST2) and circulating cell-free DNA (cfDNA) in predicting cardiac functions in children with severe pneumonia complicated by myocardial damage. Methods: This case series study evaluated the serum sST2 and cfDNA levels of 60 children with severe pneumonia complicated by myocardial damage, assessing clinical data, biomarker levels, and cardiac function. Results: We analyzed data from a cohort of 60 patients with a mean age of 4.47±1.88 years and a male: female ratio of 28:32. At baseline, patients had elevated levels of serum biomarkers, including sST2 and cfDNA, which were associated with cardiac function parameters and clinical outcomes. After 6 months, patients showed significant correlations between sST2, cfDNA, and cardiac function parameters, including left ventricular end-diastolic diameter (LVEDd), left ventricular end-systolic diameter (LVESd), and E/A ratio. Multivariate analysis revealed that higher levels of sST2 and cfDNA were associated with increased LVEDd, LVESd, and E/A ratio, as well as a lower likelihood of improvement and a higher likelihood of 6-month readmission. Conclusions: These findings suggest that sST2 and cfDNA may be useful biomarkers for predicting cardiac function and outcomes in this patient population.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502264Z.pdfsst2cfdnasevere pneumonia complicated by myocardial damagecardiac functions |
| spellingShingle | Zhao Tingting Liu Ye Jia Haoran Wang Dexing Du Meng Wang Weiwei The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage Journal of Medical Biochemistry sst2 cfdna severe pneumonia complicated by myocardial damage cardiac functions |
| title | The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage |
| title_full | The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage |
| title_fullStr | The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage |
| title_full_unstemmed | The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage |
| title_short | The significance of serum sST2 and cfDNA in children with severe pneumonia complicated by myocardial damage |
| title_sort | significance of serum sst2 and cfdna in children with severe pneumonia complicated by myocardial damage |
| topic | sst2 cfdna severe pneumonia complicated by myocardial damage cardiac functions |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2025/1452-82582502264Z.pdf |
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