Guanine holes are prominent targets for mutation in cancer and inherited disease.

Guanine holes are prominent targets for mutation in cancer and inherited disease.

Single base substitutions constitute the most frequent type of human gene mutation and are a leading cause of cancer and inherited disease. These alterations occur non-randomly in DNA, being strongly influenced by the local nucleotide sequence context. However, the molecular mechanisms underlying su...

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Main Authors: Albino Bacolla, Nuri A Temiz, Ming Yi, Joseph Ivanic, Regina Z Cer, Duncan E Donohue, Edward V Ball, Uma S Mudunuri, Guliang Wang, Aklank Jain, Natalia Volfovsky, Brian T Luke, Robert M Stephens, David N Cooper, Jack R Collins, Karen M Vasquez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003816&type=printable
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