Basic implications on three pathways associated with SARS-CoV-2

Basic implications on three pathways associated with SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts. Its pathophysiology involves the followings: 1) the angiotensin-converting enzyme (ACE2) and Toll-like receptor (TLR) pathways: 2) the neuropilin (...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jong hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman
Format:	Article
Language:	English
Published:	Elsevier 2025-04-01
Series:	Biomedical Journal
Subjects:	ACE2 SARS-CoV-2 Spike protein TLR COVID-19
Online Access:	http://www.sciencedirect.com/science/article/pii/S2319417024000696
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane
by: Piergiorgio La Rosa, et al.
Published: (2024-12-01)

The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation
by: Ming-Shiu Lin, et al.
Published: (2025-06-01)

In Vitro Inhibitory Effect of Nigella sativa L. Extracts on SARS-COV-2 Spike Protein-ACE2 Interaction
by: Najma Ali, et al.
Published: (2024-01-01)

Potential Beneficial Role of Nitric Oxide in SARS-CoV-2 Infection: Beyond Spike-Binding Inhibition
by: Sergio Sánchez-García, et al.
Published: (2024-10-01)

Host susceptibilities and entry processes of SARS-CoV-2 Omicron variants using pseudotyped viruses carrying spike protein
by: Alexandria Zabiegala, et al.
Published: (2025-05-01)

Impedimetric Sensor for SARS-CoV-2 Spike Protein Detection: Performance Assessment with an ACE2 Peptide-Mimic/Graphite Interface
by: Diego Quezada, et al.
Published: (2024-12-01)

Computational electrostatic engineering of nanobodies for enhanced SARS−CoV−2 receptor binding domain recognition
by: Zafar Iqbal, et al.
Published: (2025-03-01)

Biochemical analysis of packing and assembling heptad repeat motifs in the coronavirus spike protein trimer
by: Jun Kobayashi, et al.
Published: (2024-11-01)

Disrupting SARS-CoV-2 Spike–ACE2 Interactions via Glycosaminoglycans in a Pseudoviral Study of Heparan Sulfate and Enoxaparin
by: Virginia Fuochi, et al.
Published: (2025-06-01)

Natural compounds from ethno-medicinal plants exhibit multiple binding activities on SARS-CoV-2 spike protein receptor-binding domains
by: Trizah K. Milugo, et al.
Published: (2025-05-01)

Computational Design and Evaluation of Peptides to Target SARS-CoV-2 Spike–ACE2 Interaction
by: Saja Almabhouh, et al.
Published: (2025-04-01)

Temporal correlations between RBD-ACE2 blocking and binding antibodies to SARS-CoV-2 variants in CoronaVac-vaccinated individuals and their persistence in COVID-19 patients
by: Prapassorn Poolchanuan, et al.
Published: (2025-05-01)

SARS-CoV-2 viral proteins trigger pain via TLR2/4-MyD88 pathway
by: Wenliang Su, et al.
Published: (2025-06-01)

Relationship of ACE1 and ACE2 genetic polymorphisms on SARS-CoV-2 infection and severity of symptoms in different regions of Iraq
by: Bilal Ali Khashan, et al.
Published: (2024-02-01)

Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
by: Siu-Ying Lau, et al.
Published: (2020-01-01)

Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry
by: Weiyi Chen, et al.
Published: (2025-08-01)

ACE2 and TMPRSS2 gene expression is reduced acutely in SARS-CoV-2 patients but returns to normal with recovery
by: Vanessa Hui En Chen, et al.
Published: (2025-04-01)

The Immunologic Downsides Associated with the Powerful Translation of Current COVID-19 Vaccine mRNA Can Be Overcome by Mucosal Vaccines
by: Maurizio Federico
Published: (2024-11-01)

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells
by: Sunhee Lee, et al.
Published: (2020-01-01)

Plants Metabolites as In Vitro Inhibitors of SARS-CoV-2 Targets: A Systematic Review and Computational Analysis
by: Brendo Araujo Gomes, et al.
Published: (2025-06-01)

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection
by: Julian Heuberger, et al.
Published: (2021-03-01)

Evolutionary Analysis of Mammalian ACE2 and the Key Residues Involved in Binding to the Spike Protein Revealed Potential SARS-CoV-2 Hosts
by: Luciano Rodrigo Lopes1, et al.
Published: (2022-03-01)

Effects of SARS-CoV-2 on the cardiovascular system: More issues to be addressed
by: Yang Liu
Published: (2020-07-01)

RISK FOR PNEUMONIA AND TLR2 AND TLR4 GENE POLYMORPHISMS: A META-ANALYSIS
by: S. V. Smirnova, et al.
Published: (2016-01-01)

Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes
by: Henrique Low Nogueira, et al.
Published: (2024-12-01)

Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes
by: Henrique Low Nogueira, et al.
Published: (2024-12-01)

Expression Levels of Intestinal Toll-Like Receptors 2 and 4 in Acute Inflammation Caused by Intestinal Candidiasis: An Experimental Study in Wistar Rats
by: Putu Oky Ari Tania, et al.
Published: (2024-09-01)

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
by: Endika Prieto-Fernández, et al.
Published: (2021-01-01)

The ACE2 Receptor from Common Vampire Bat (<i>Desmodus rotundus</i>) and Pallid Bat (<i>Antrozous pallidus</i>) Support Attachment and Limited Infection of SARS-CoV-2 Viruses in Cell Culture
by: Abhijeet Bakre, et al.
Published: (2025-03-01)

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection
by: Raveen Rathnasinghe, et al.
Published: (2020-01-01)

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection
by: Salyan Bhattarai, et al.
Published: (2025-02-01)

Characterization of key spike RBD residues influencing SARS-CoV-2 variant adaptation to avian ACE2
by: Weitong Yao, et al.
Published: (2025-07-01)

Pulmonary tuberculosis susceptibility and association with Toll-Like receptor 2 Arg753Gln polymorphism
by: Eman A El-Masry, et al.
Published: (2022-01-01)

The Innovative Method for Vaccine Preparation Against Multidrug Resistant and Virulence Acinetobacter baumannii Iraqi Isolates
by: Baghdad Science Journal
Published: (2017-12-01)

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
by: L. V. Gankovskaya, et al.
Published: (2017-08-01)

An ACE2-Fc decoy produced in glycoengineered plants neutralizes ancestral and newly emerging SARS-CoV-2 variants and demonstrates therapeutic efficacy in hamsters
by: Esther Föderl-Höbenreich, et al.
Published: (2025-04-01)

Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic
by: Temitope Isaac Adelusi, et al.
Published: (2025-01-01)

Potential Resistance Mechanisms Exhibited by Cystic Fibrosis Patients Against SARS-CoV-2
by: Yasmin K. Elsharabassi, et al.
Published: (2025-06-01)

Altered plasma levels of the SARS-CoV-2-related proteins ACE2 and TMPRSS2 in patients with Crohn’s disease
by: Jorge Sáez-Leyva, et al.
Published: (2024-12-01)

Comparative Analysis of Host Cell Entry Efficiency and Neutralization Sensitivity of Emerging SARS-CoV-2 Lineages KP.2, KP.2.3, KP.3, and LB.1
by: Nianzhen Chen, et al.
Published: (2024-10-01)