Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study
Objective. To investigate the role of acetylsalicylic acid (ASA) in reducing the incidence of cardiovascular (CV) events in an Italian multicentre rheumatoid arthritis (RA) inception cohort. Methods. The clinical charts of RA patients consecutively admitted to 4 Italian centres for their 1st visit f...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/2748035 |
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| author | Daniela Iacono Serena Fasano Ilenia Pantano Virginia D’Abrosca Piero Ruscitti Domenico Paolo Emanuele Margiotta Luca Navarini Nicola Maruotti Rosa Daniela Grembiale Francesco Paolo Cantatore Antonella Afeltra Roberto Giacomelli Gabriele Valentini |
| author_facet | Daniela Iacono Serena Fasano Ilenia Pantano Virginia D’Abrosca Piero Ruscitti Domenico Paolo Emanuele Margiotta Luca Navarini Nicola Maruotti Rosa Daniela Grembiale Francesco Paolo Cantatore Antonella Afeltra Roberto Giacomelli Gabriele Valentini |
| author_sort | Daniela Iacono |
| collection | DOAJ |
| description | Objective. To investigate the role of acetylsalicylic acid (ASA) in reducing the incidence of cardiovascular (CV) events in an Italian multicentre rheumatoid arthritis (RA) inception cohort. Methods. The clinical charts of RA patients consecutively admitted to 4 Italian centres for their 1st visit from November 1, 2000, to December 31, 2015, and followed up till December 2016 were retrospectively investigated for the incidence of CV events. Patients were subdivided into two groups, namely, ASA- and non-ASA-treated groups. The Kaplan–Meier curve and log-rank test were used to investigate differences in event-free survival. Cox regression analysis was carried out to identify factors associated with CV event occurrence. Results. Seven hundred forty-six consecutive RA patients were enrolled and followed up for a median of 5.6 years (range 2.9–8.9 years). The incidence rate (IR) of CV events was 8/1000 person-years (p-ys) in the overall cohort. The IR of CV events was significantly lower in the ASA-treated group with respect to the non-ASA-treated group (IR 1.7 vs. 11.8/1000 p-ys; p=0.0002). The CV event-free rate was longer in ASA-treated patients than in non-ASA-treated patients (log-rank test 12.8; p=0.0003). At multivariable analysis, arterial hypertension (HR 9.3) and hypercholesterolemia (HR 2.8) resulted to be positive predictors and ASA (HR 0.09) and hydroxychloroquine (HCQ) (HR 0.22) to be negative predictors. Conclusion. The IR of CV events in our Italian multicentre cohort was lower than that reported in other European and non-European cohorts. Low-dose ASA may have a role in the primary prophylaxis of CV events in RA patients. |
| format | Article |
| id | doaj-art-14a9a053d75d44968ede54d2aa6aa498 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-14a9a053d75d44968ede54d2aa6aa4982025-02-03T01:01:57ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/27480352748035Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective StudyDaniela Iacono0Serena Fasano1Ilenia Pantano2Virginia D’Abrosca3Piero Ruscitti4Domenico Paolo Emanuele Margiotta5Luca Navarini6Nicola Maruotti7Rosa Daniela Grembiale8Francesco Paolo Cantatore9Antonella Afeltra10Roberto Giacomelli11Gabriele Valentini12Rheumatology Section, University of Campania “Luigi Vanvitelli”, Naples, ItalyRheumatology Section, University of Campania “Luigi Vanvitelli”, Naples, ItalyRheumatology Section, University of Campania “Luigi Vanvitelli”, Naples, ItalyRheumatology Section, University of Campania “Luigi Vanvitelli”, Naples, ItalyDivision of Rheumatology, University of L’Aquila, L’Aquila, ItalyUnit of Rheumatology, Università Campus Bio-Medico di Roma, Rome, ItalyUnit of Rheumatology, Università Campus Bio-Medico di Roma, Rome, ItalyRheumatology Clinic, University of Foggia Medical School, Foggia, ItalyRheumatology Unit, University of Magna Grecia, Catanzaro, ItalyRheumatology Clinic, University of Foggia Medical School, Foggia, ItalyUnit of Rheumatology, Università Campus Bio-Medico di Roma, Rome, ItalyDivision of Rheumatology, University of L’Aquila, L’Aquila, ItalyRheumatology Section, University of Campania “Luigi Vanvitelli”, Naples, ItalyObjective. To investigate the role of acetylsalicylic acid (ASA) in reducing the incidence of cardiovascular (CV) events in an Italian multicentre rheumatoid arthritis (RA) inception cohort. Methods. The clinical charts of RA patients consecutively admitted to 4 Italian centres for their 1st visit from November 1, 2000, to December 31, 2015, and followed up till December 2016 were retrospectively investigated for the incidence of CV events. Patients were subdivided into two groups, namely, ASA- and non-ASA-treated groups. The Kaplan–Meier curve and log-rank test were used to investigate differences in event-free survival. Cox regression analysis was carried out to identify factors associated with CV event occurrence. Results. Seven hundred forty-six consecutive RA patients were enrolled and followed up for a median of 5.6 years (range 2.9–8.9 years). The incidence rate (IR) of CV events was 8/1000 person-years (p-ys) in the overall cohort. The IR of CV events was significantly lower in the ASA-treated group with respect to the non-ASA-treated group (IR 1.7 vs. 11.8/1000 p-ys; p=0.0002). The CV event-free rate was longer in ASA-treated patients than in non-ASA-treated patients (log-rank test 12.8; p=0.0003). At multivariable analysis, arterial hypertension (HR 9.3) and hypercholesterolemia (HR 2.8) resulted to be positive predictors and ASA (HR 0.09) and hydroxychloroquine (HCQ) (HR 0.22) to be negative predictors. Conclusion. The IR of CV events in our Italian multicentre cohort was lower than that reported in other European and non-European cohorts. Low-dose ASA may have a role in the primary prophylaxis of CV events in RA patients.http://dx.doi.org/10.1155/2019/2748035 |
| spellingShingle | Daniela Iacono Serena Fasano Ilenia Pantano Virginia D’Abrosca Piero Ruscitti Domenico Paolo Emanuele Margiotta Luca Navarini Nicola Maruotti Rosa Daniela Grembiale Francesco Paolo Cantatore Antonella Afeltra Roberto Giacomelli Gabriele Valentini Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study Cardiology Research and Practice |
| title | Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study |
| title_full | Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study |
| title_fullStr | Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study |
| title_full_unstemmed | Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study |
| title_short | Low-Dose Aspirin as Primary Prophylaxis for Cardiovascular Events in Rheumatoid Arthritis: An Italian Multicentre Retrospective Study |
| title_sort | low dose aspirin as primary prophylaxis for cardiovascular events in rheumatoid arthritis an italian multicentre retrospective study |
| url | http://dx.doi.org/10.1155/2019/2748035 |
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