Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design
This research aimed to optimize the extraction conditions of phenolic compounds by ultrasound-assisted extraction (UAE) from <i>Cornulaca monacantha</i> Del., a species of the Chenopodiaceae family, using response surface methodology (RSM). A three-level Box–Behnken Design was used to in...
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2025-04-01
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| author | Sara Lemmadi Faïza Adoui Emilie Dumas Samira Karoune Cyrille Santerre Adem Gharsallaoui |
| author_facet | Sara Lemmadi Faïza Adoui Emilie Dumas Samira Karoune Cyrille Santerre Adem Gharsallaoui |
| author_sort | Sara Lemmadi |
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| description | This research aimed to optimize the extraction conditions of phenolic compounds by ultrasound-assisted extraction (UAE) from <i>Cornulaca monacantha</i> Del., a species of the Chenopodiaceae family, using response surface methodology (RSM). A three-level Box–Behnken Design was used to investigate the following three factors of extraction conditions: solid-to-liquid ratio (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula>), extraction temperature (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>j</mi></mrow></msub></mrow></semantics></math></inline-formula>), and extraction time (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>k</mi></mrow></msub></mrow></semantics></math></inline-formula>). The optimized UAE extraction conditions obtained were: (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 0.5:10 g/mL, (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>j</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 45 °C, and (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>k</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 30 min. Once the extraction conditions of the phenolic compounds had been optimized, this protocol was applied to another plant of the same family, <i>Anabasis articulata</i> (Frossk.) Moq. The optimum values of extraction yield, total polyphenol content (TPC), and total flavonoid content (TFC) were respectively 14.68%, 37.27 (µg GAE/mg DE), and 7.21 (µg QE/mg DE) for <i>Cornulaca monacantha</i> Del., and 13.56%, 58.38 (µg GAE/mg DE), and 6.44 (µg QE/mg DE) for <i>Anabasis articulata</i> (Frossk.) Moq. <i>Anabasis articulata</i> (Frossk.) Moq. has a significantly higher antioxidant potential than <i>Cornulaca monacantha</i> Del. due to its high content of phenolic compounds (TPC). The high concentration of these plants in phenolic compounds validates their potential for traditional medicinal use. |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-14a7b35d61824b03b7b7f4f0be2d45e72025-08-20T01:49:48ZengMDPI AGApplied Sciences2076-34172025-04-01159468810.3390/app15094688Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken DesignSara Lemmadi0Faïza Adoui1Emilie Dumas2Samira Karoune3Cyrille Santerre4Adem Gharsallaoui5Laboratoire de Génie Agro-Alimentaire (GENIAAL), Institut de la Nutrition, de l’Alimentation et des Technologies Agro-Alimentaires (INATAA), Université Frères Mentouri Constantine 1, Route de Ain El-Bey, Constantine 25000, AlgeriaLaboratoire de Génie Agro-Alimentaire (GENIAAL), Institut de la Nutrition, de l’Alimentation et des Technologies Agro-Alimentaires (INATAA), Université Frères Mentouri Constantine 1, Route de Ain El-Bey, Constantine 25000, AlgeriaUniv Lyon, Université Claude Bernard Lyon 1, CNRS, LAGEPP UMR 5007, F-69100 Villeurbanne, FranceCentre de Recherche Scientifique et Techniques sur les Régions Arides (CRSTRA), Biskra 07000, AlgeriaInstitut Supérieur International du Parfum, de la Cosmétique et de l’Aromatique Alimentaire (ISIPCA), 34-36 Rue du Parc de Clagny, F-78000 Versailles, FranceUniv Lyon, Université Claude Bernard Lyon 1, CNRS, LAGEPP UMR 5007, F-69100 Villeurbanne, FranceThis research aimed to optimize the extraction conditions of phenolic compounds by ultrasound-assisted extraction (UAE) from <i>Cornulaca monacantha</i> Del., a species of the Chenopodiaceae family, using response surface methodology (RSM). A three-level Box–Behnken Design was used to investigate the following three factors of extraction conditions: solid-to-liquid ratio (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula>), extraction temperature (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>j</mi></mrow></msub></mrow></semantics></math></inline-formula>), and extraction time (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>k</mi></mrow></msub></mrow></semantics></math></inline-formula>). The optimized UAE extraction conditions obtained were: (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>i</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 0.5:10 g/mL, (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>j</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 45 °C, and (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>X</mi></mrow><mrow><mi>k</mi></mrow></msub></mrow></semantics></math></inline-formula>) = 30 min. Once the extraction conditions of the phenolic compounds had been optimized, this protocol was applied to another plant of the same family, <i>Anabasis articulata</i> (Frossk.) Moq. The optimum values of extraction yield, total polyphenol content (TPC), and total flavonoid content (TFC) were respectively 14.68%, 37.27 (µg GAE/mg DE), and 7.21 (µg QE/mg DE) for <i>Cornulaca monacantha</i> Del., and 13.56%, 58.38 (µg GAE/mg DE), and 6.44 (µg QE/mg DE) for <i>Anabasis articulata</i> (Frossk.) Moq. <i>Anabasis articulata</i> (Frossk.) Moq. has a significantly higher antioxidant potential than <i>Cornulaca monacantha</i> Del. due to its high content of phenolic compounds (TPC). The high concentration of these plants in phenolic compounds validates their potential for traditional medicinal use.https://www.mdpi.com/2076-3417/15/9/4688Chenopodiaceae familyBox–Behnken designultrasound-assisted extractionphenolic compoundsantioxidant activity |
| spellingShingle | Sara Lemmadi Faïza Adoui Emilie Dumas Samira Karoune Cyrille Santerre Adem Gharsallaoui Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design Applied Sciences Chenopodiaceae family Box–Behnken design ultrasound-assisted extraction phenolic compounds antioxidant activity |
| title | Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design |
| title_full | Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design |
| title_fullStr | Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design |
| title_full_unstemmed | Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design |
| title_short | Optimization of Ultrasound-Assisted Extraction of Phenolic Compounds from the Aerial Part of Plants in the Chenopodiaceae Family Using a Box–Behnken Design |
| title_sort | optimization of ultrasound assisted extraction of phenolic compounds from the aerial part of plants in the chenopodiaceae family using a box behnken design |
| topic | Chenopodiaceae family Box–Behnken design ultrasound-assisted extraction phenolic compounds antioxidant activity |
| url | https://www.mdpi.com/2076-3417/15/9/4688 |
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