Precise modulation of protein refolding by rationally designed covalent organic frameworks

Precise modulation of protein refolding by rationally designed covalent organic frameworks

Abstract Precisely regulating protein conformation (folding) for biomanufacturing and biomedicine is of great significance but remains challenging. In this work, we innovate a covalent organic framework (COF)-directed protein refolding strategy to modulate protein conformation by rationally designed...

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Bibliographic Details
Main Authors: Jinbiao Guo, Xiaoyu Sun, Jian Wang, Yimiao Hou, Mingfang Yang, Junjie Tan, Zhenjie Zhang, Yao Chen, Wen Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59368-z
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