Evaluating Vitamin C Vaginal Tablets Effect on Gardnerella vaginalis Infection
Introduction: Bacterial vaginosis (BV) is the most common vaginitis in childbearing women. Despite the availability of various treatments, recurrence rates are high. This study investigated the effects and side effects of vitamin C vaginal tablets in patients with Gardnerella vaginalis infection...
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2023-09-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://jommid.pasteur.ac.ir/article-1-391-en.html |
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| Summary: | Introduction: Bacterial vaginosis (BV) is the most common vaginitis in
childbearing women. Despite the availability of various treatments,
recurrence rates are high. This study investigated the effects and side effects
of vitamin C vaginal tablets in patients with Gardnerella vaginalis infection
based on Amsel criteria and the culture. Methods: A double-blind,
randomized clinical trial was conducted on 48 non-pregnant women aged
15-40 years referred to Alawi Hospital in Ardabil Province, Iran. After the
diagnosis of G. vaginalis infection based on Amsel criteria and culture
methods, the patients were randomly assigned to receive either intravaginal
250 mg vitamin C (intervention group, n=24) or 250 mg metronidazole
tablets (control group, n=24) for eight nights. The patients were evaluated
10 ± 2 and 30 ± 2 days before and after the treatment. Results: Culture and
Amsel criteria showed significant improvement in both groups during the
first and fourth weeks of treatment. However, the intervention group that
received vitamin C showed a more substantial improvement (P<0.002,
P<0.001). Intravaginal vitamin tablets were more effective than
metronidazole tablets in treating G. vaginalis infection. Furthermore,
vitamin C tablets improved the abnormal growth of vaginal microflora and
reduced the abnormally high pH of the vagina. This treatment effectively
prevented the recurrence of G. vaginalis infection for one month.
Conclusion: Vitamin C vaginal tablets showed to be a promising alternative
treatment for G. vaginalis infection, but further research is needed to confirm
these findings and address potential limitations. |
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| ISSN: | 2345-5349 2345-5330 |