Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients
Jose Miguel Escamilla-Gil,1– 3 Carlos A Torres-Duque,2,3 Kevin Llinás-Caballero,1 Nadia Juliana Proaños-Jurado,2,3 María M De Vivero,1 Jonathan Camilo Ramirez,1 Ronald Regino,1 Lucila Teresa Florez de Arco,4 Rodolfo Dennis,5,6 Mauricio González-García,2,3 Luis Caraballo,1 Nathalie Acevedo1 1Institut...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2025-04-01
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| Series: | International Journal of COPD |
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| Online Access: | https://www.dovepress.com/plasma-levels-of-cxcl9-and-mcp-3-are-increased-in-asthma-copd-overlap--peer-reviewed-fulltext-article-COPD |
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| author | Escamilla-Gil JM Torres-Duque CA Llinás-Caballero K Proaños-Jurado NJ De Vivero MM Ramirez JC Regino R Florez de Arco LT Dennis R González-García M Caraballo L Acevedo N |
| author_facet | Escamilla-Gil JM Torres-Duque CA Llinás-Caballero K Proaños-Jurado NJ De Vivero MM Ramirez JC Regino R Florez de Arco LT Dennis R González-García M Caraballo L Acevedo N |
| author_sort | Escamilla-Gil JM |
| collection | DOAJ |
| description | Jose Miguel Escamilla-Gil,1– 3 Carlos A Torres-Duque,2,3 Kevin Llinás-Caballero,1 Nadia Juliana Proaños-Jurado,2,3 María M De Vivero,1 Jonathan Camilo Ramirez,1 Ronald Regino,1 Lucila Teresa Florez de Arco,4 Rodolfo Dennis,5,6 Mauricio González-García,2,3 Luis Caraballo,1 Nathalie Acevedo1 1Institute for Immunological Research, University of Cartagena, Cartagena, Colombia; 2CINEUMO, Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; 3La Sabana University, School of Medicine, Bogotá, Colombia; 4Respiratory and Allergy Clinic, Cartagena, Colombia; 5Cardioinfantil Foundation, Bogotá, Colombia; 6Universidad del Rosario, Bogotá, ColombiaCorrespondence: Nathalie Acevedo, Institute for Immunological Research. University of Cartagena. Health Sciences Campus Zaragocilla. Ed. Biblioteca Piso 1, Cartagena, 1300014, Colombia, Email nacevedoc@unicartagena.edu.coPurpose: Asthma and chronic obstructive pulmonary disease overlap patients (ACO) have more exacerbations and a worse prognosis than pure asthma or COPD, and it is of great interest to identify differential biomarkers of ACO. We compared blood eosinophil counts, plasma IgE and protein levels among patients with asthma, ACO, COPD, and healthy subjects to identify those associated with ACO.Patients and Methods: 397 adults (age 40– 90 years) were recruited from two Colombian cities: asthma (n=123), COPD (n=100), ACO (n=74) and healthy control (HC, n=100). Plasma protein levels were measured using the Proximity Extension Assay (Olink Proteomics).Results: There were no differences in blood eosinophil counts between the patient groups. Total and specified IgE levels were higher in patients with ACO than in those with COPD. Ten plasma proteins showed significant differences between the patients with ACO and HC. In patients above 60 years old, CXCL9 discriminates ACO from asthma patients with AUC 0.73 (0.63– 0.82, DeLong test p=0.007), and in patients below 60 years old, MCP-3 discriminates ACO from COPD patients with AUC 0.84 (0.62– 1.0, DeLong test p=0.006). CUB domain-containing protein 1 (CDCP1) levels (OR, 0.47; p=0.008) and age > 60 years (OR, 0.25; p=0.001) were negatively associated with ACO.Conclusion: CXCL9 levels could be used to discriminate ACO from asthma patients and MCP-3 to discriminate ACO from COPD. Protein inflammatory signatures in plasma of ACO patients were similar to the COPD group. This study revealed novel biomarkers that may help characterize patients with ACO.Keywords: biomarkers, proximity extension assay, PEA, chronic obstructive pulmonary disease, COPD, circulating inflammatory mediators, CXCL9, MCP-3 |
| format | Article |
| id | doaj-art-149fa87cd7f14436b53b6839d88430f3 |
| institution | OA Journals |
| issn | 1178-2005 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj-art-149fa87cd7f14436b53b6839d88430f32025-08-20T01:47:55ZengDove Medical PressInternational Journal of COPD1178-20052025-04-01Volume 2011611174102287Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) PatientsEscamilla-Gil JMTorres-Duque CALlinás-Caballero KProaños-Jurado NJDe Vivero MMRamirez JCRegino RFlorez de Arco LTDennis RGonzález-García MCaraballo LAcevedo NJose Miguel Escamilla-Gil,1– 3 Carlos A Torres-Duque,2,3 Kevin Llinás-Caballero,1 Nadia Juliana Proaños-Jurado,2,3 María M De Vivero,1 Jonathan Camilo Ramirez,1 Ronald Regino,1 Lucila Teresa Florez de Arco,4 Rodolfo Dennis,5,6 Mauricio González-García,2,3 Luis Caraballo,1 Nathalie Acevedo1 1Institute for Immunological Research, University of Cartagena, Cartagena, Colombia; 2CINEUMO, Research Center, Fundación Neumológica Colombiana, Bogotá, Colombia; 3La Sabana University, School of Medicine, Bogotá, Colombia; 4Respiratory and Allergy Clinic, Cartagena, Colombia; 5Cardioinfantil Foundation, Bogotá, Colombia; 6Universidad del Rosario, Bogotá, ColombiaCorrespondence: Nathalie Acevedo, Institute for Immunological Research. University of Cartagena. Health Sciences Campus Zaragocilla. Ed. Biblioteca Piso 1, Cartagena, 1300014, Colombia, Email nacevedoc@unicartagena.edu.coPurpose: Asthma and chronic obstructive pulmonary disease overlap patients (ACO) have more exacerbations and a worse prognosis than pure asthma or COPD, and it is of great interest to identify differential biomarkers of ACO. We compared blood eosinophil counts, plasma IgE and protein levels among patients with asthma, ACO, COPD, and healthy subjects to identify those associated with ACO.Patients and Methods: 397 adults (age 40– 90 years) were recruited from two Colombian cities: asthma (n=123), COPD (n=100), ACO (n=74) and healthy control (HC, n=100). Plasma protein levels were measured using the Proximity Extension Assay (Olink Proteomics).Results: There were no differences in blood eosinophil counts between the patient groups. Total and specified IgE levels were higher in patients with ACO than in those with COPD. Ten plasma proteins showed significant differences between the patients with ACO and HC. In patients above 60 years old, CXCL9 discriminates ACO from asthma patients with AUC 0.73 (0.63– 0.82, DeLong test p=0.007), and in patients below 60 years old, MCP-3 discriminates ACO from COPD patients with AUC 0.84 (0.62– 1.0, DeLong test p=0.006). CUB domain-containing protein 1 (CDCP1) levels (OR, 0.47; p=0.008) and age > 60 years (OR, 0.25; p=0.001) were negatively associated with ACO.Conclusion: CXCL9 levels could be used to discriminate ACO from asthma patients and MCP-3 to discriminate ACO from COPD. Protein inflammatory signatures in plasma of ACO patients were similar to the COPD group. This study revealed novel biomarkers that may help characterize patients with ACO.Keywords: biomarkers, proximity extension assay, PEA, chronic obstructive pulmonary disease, COPD, circulating inflammatory mediators, CXCL9, MCP-3https://www.dovepress.com/plasma-levels-of-cxcl9-and-mcp-3-are-increased-in-asthma-copd-overlap--peer-reviewed-fulltext-article-COPDbiomarkersproximity extension assaychronic obstructive pulmonary diseasecirculating inflammatory mediatorscxcl9mcp-3 |
| spellingShingle | Escamilla-Gil JM Torres-Duque CA Llinás-Caballero K Proaños-Jurado NJ De Vivero MM Ramirez JC Regino R Florez de Arco LT Dennis R González-García M Caraballo L Acevedo N Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients International Journal of COPD biomarkers proximity extension assay chronic obstructive pulmonary disease circulating inflammatory mediators cxcl9 mcp-3 |
| title | Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients |
| title_full | Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients |
| title_fullStr | Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients |
| title_full_unstemmed | Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients |
| title_short | Plasma Levels of CXCL9 and MCP-3 are Increased in Asthma-COPD Overlap (ACO) Patients |
| title_sort | plasma levels of cxcl9 and mcp 3 are increased in asthma copd overlap aco patients |
| topic | biomarkers proximity extension assay chronic obstructive pulmonary disease circulating inflammatory mediators cxcl9 mcp-3 |
| url | https://www.dovepress.com/plasma-levels-of-cxcl9-and-mcp-3-are-increased-in-asthma-copd-overlap--peer-reviewed-fulltext-article-COPD |
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