Acute Niclofolan Intoxication Led to Stillbirth: A Case Report
Rui Feng Li,1,* Liang Fen Wang,1,2,* Hai Ying Zhang,3 Meng Jie He1 1Department of Clinical Pharmacy, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Pharm...
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Dove Medical Press
2025-01-01
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| author | Li RF Wang LF Zhang HY He MJ |
| author_facet | Li RF Wang LF Zhang HY He MJ |
| author_sort | Li RF |
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| description | Rui Feng Li,1,* Liang Fen Wang,1,2,* Hai Ying Zhang,3 Meng Jie He1 1Department of Clinical Pharmacy, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Pharmacy, 363 hospital, Chengdu, People’s Republic of China; 3Medical Intensive Care Unit, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meng Jie He, Department of Clinical Pharmacy, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, No. 290, Shayan West 2nd Street, Chengdu, 610014, People’s Republic of China, Email mengjie161003@163.comAbstract: Niclofolan is a commonly used veterinary drug worldwide. We reported a case of acute niclofolan intoxication in a pregnant woman. We recorded in detail her toxic symptoms, including nausea, vomiting, asthenia, blurred vision, and aberrant blood values. Notably stillbirth was recorded for the first time as indicating its human reproductive toxicity. We also found that an oral therapeutic dosage as described in the literature was likely to lead to stillbirth. Furthermore, we described the treatments received by the patient, including critical care, drug therapy, and plasma exchange, the outcomes of which were excellent. By studying this case, we aimed to enhance recognition and treatment of niclofolan intoxication and to raise concern regarding veterinary drug abuse and exposure risk.Keywords: niclofolan intoxication, reproductive toxicity, intensive healthcare, case report |
| format | Article |
| id | doaj-art-149a4546337e4064b14de2df94f92e78 |
| institution | Kabale University |
| issn | 1179-1365 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug, Healthcare and Patient Safety |
| spelling | doaj-art-149a4546337e4064b14de2df94f92e782025-01-07T16:42:40ZengDove Medical PressDrug, Healthcare and Patient Safety1179-13652025-01-01Volume 171698975Acute Niclofolan Intoxication Led to Stillbirth: A Case ReportLi RFWang LFZhang HYHe MJRui Feng Li,1,* Liang Fen Wang,1,2,* Hai Ying Zhang,3 Meng Jie He1 1Department of Clinical Pharmacy, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Pharmacy, 363 hospital, Chengdu, People’s Republic of China; 3Medical Intensive Care Unit, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meng Jie He, Department of Clinical Pharmacy, Sichuan Provincial Women’s and Children’s Hospital/The Affiliated Women’s and Children’s Hospital of Chengdu Medical College, No. 290, Shayan West 2nd Street, Chengdu, 610014, People’s Republic of China, Email mengjie161003@163.comAbstract: Niclofolan is a commonly used veterinary drug worldwide. We reported a case of acute niclofolan intoxication in a pregnant woman. We recorded in detail her toxic symptoms, including nausea, vomiting, asthenia, blurred vision, and aberrant blood values. Notably stillbirth was recorded for the first time as indicating its human reproductive toxicity. We also found that an oral therapeutic dosage as described in the literature was likely to lead to stillbirth. Furthermore, we described the treatments received by the patient, including critical care, drug therapy, and plasma exchange, the outcomes of which were excellent. By studying this case, we aimed to enhance recognition and treatment of niclofolan intoxication and to raise concern regarding veterinary drug abuse and exposure risk.Keywords: niclofolan intoxication, reproductive toxicity, intensive healthcare, case reporthttps://www.dovepress.com/acute-niclofolan-intoxication-led-to-stillbirth-a-case-report-peer-reviewed-fulltext-article-DHPSniclofolan intoxicationreproductive toxicityintensive healthcarecase report |
| spellingShingle | Li RF Wang LF Zhang HY He MJ Acute Niclofolan Intoxication Led to Stillbirth: A Case Report Drug, Healthcare and Patient Safety niclofolan intoxication reproductive toxicity intensive healthcare case report |
| title | Acute Niclofolan Intoxication Led to Stillbirth: A Case Report |
| title_full | Acute Niclofolan Intoxication Led to Stillbirth: A Case Report |
| title_fullStr | Acute Niclofolan Intoxication Led to Stillbirth: A Case Report |
| title_full_unstemmed | Acute Niclofolan Intoxication Led to Stillbirth: A Case Report |
| title_short | Acute Niclofolan Intoxication Led to Stillbirth: A Case Report |
| title_sort | acute niclofolan intoxication led to stillbirth a case report |
| topic | niclofolan intoxication reproductive toxicity intensive healthcare case report |
| url | https://www.dovepress.com/acute-niclofolan-intoxication-led-to-stillbirth-a-case-report-peer-reviewed-fulltext-article-DHPS |
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