Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus
Abstract Objective This study aimed to assess the relationship between abdominal fat distribution (AFD) and urinary albumin/creatinine ratio (UACR) in Chinese adults. Methods 823 patients with type 2 diabetes mellitus(T2DM) were selected. Abdominal visceral fat area (VFA) and subcutaneous fat area (...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-06-01
|
| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-025-01814-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849329464495833088 |
|---|---|
| author | Tianlu Shi Ying Yang Yunxia Liu Min Zhang Junran Shu Shujin Wang Tianxiao Zhang Yu Niu |
| author_facet | Tianlu Shi Ying Yang Yunxia Liu Min Zhang Junran Shu Shujin Wang Tianxiao Zhang Yu Niu |
| author_sort | Tianlu Shi |
| collection | DOAJ |
| description | Abstract Objective This study aimed to assess the relationship between abdominal fat distribution (AFD) and urinary albumin/creatinine ratio (UACR) in Chinese adults. Methods 823 patients with type 2 diabetes mellitus(T2DM) were selected. Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were measured using bioelectrical impedance analysis (BIA). Patients were divided into four groups: low VFA /low SFA, low VFA /high SFA, high VFA /low SFA, and high VFA /high SFA based on the median values (low: < median, high: ≥median). Results In the multifactor analysis after adjusting for relevant factors, VFA, waist-to-height ratio (WHtR), waist-hip ratio (WHR), and waist circumference (WC) showed significant positive correlations with UACR, while SFA and BMI did not. AFD combinations were independent predictors of UACR. The risk of UACR30-300 mg/g was highest in the high VFA/low SFA group (OR = 3.12), and for UACR > 300 mg/g, it was highest in the high VFA/high SFA group (OR = 24.69). The areas under the receiver operating characteristic (ROC) curvefor VFA prediction of UACR ≥ 30 mg/g was 0.69, significantly greater than that for WHtR, WHR, and WC. Optimal cut-off values were 98.8 cm² for VFA. When analyzed by gender, the optimal cut-off values for VFA were 98.8 cm² for males and 102.3 cm² for females. Conclusion Central obesity indicators (VFA, WHtR, WHR, WC) were associated with UACR. VFA was the strongest predictor for UACR ≥ 30 mg/g. |
| format | Article |
| id | doaj-art-14965f6eaeff44d9b689d17923816eca |
| institution | Kabale University |
| issn | 1758-5996 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj-art-14965f6eaeff44d9b689d17923816eca2025-08-20T03:47:16ZengBMCDiabetology & Metabolic Syndrome1758-59962025-06-011711910.1186/s13098-025-01814-5Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitusTianlu Shi0Ying Yang1Yunxia Liu2Min Zhang3Junran Shu4Shujin Wang5Tianxiao Zhang6Yu Niu7Department of Endocrinology, The Ninth Hospital of Xi’anDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong UniversityDepartment of Endocrinology, The Ninth Hospital of Xi’anDepartment of Endocrinology, The Ninth Hospital of Xi’anDepartment of Endocrinology, The Ninth Hospital of Xi’anDepartment of Endocrinology, The Ninth Hospital of Xi’anDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong UniversityDepartment of Endocrinology, The Ninth Hospital of Xi’anAbstract Objective This study aimed to assess the relationship between abdominal fat distribution (AFD) and urinary albumin/creatinine ratio (UACR) in Chinese adults. Methods 823 patients with type 2 diabetes mellitus(T2DM) were selected. Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were measured using bioelectrical impedance analysis (BIA). Patients were divided into four groups: low VFA /low SFA, low VFA /high SFA, high VFA /low SFA, and high VFA /high SFA based on the median values (low: < median, high: ≥median). Results In the multifactor analysis after adjusting for relevant factors, VFA, waist-to-height ratio (WHtR), waist-hip ratio (WHR), and waist circumference (WC) showed significant positive correlations with UACR, while SFA and BMI did not. AFD combinations were independent predictors of UACR. The risk of UACR30-300 mg/g was highest in the high VFA/low SFA group (OR = 3.12), and for UACR > 300 mg/g, it was highest in the high VFA/high SFA group (OR = 24.69). The areas under the receiver operating characteristic (ROC) curvefor VFA prediction of UACR ≥ 30 mg/g was 0.69, significantly greater than that for WHtR, WHR, and WC. Optimal cut-off values were 98.8 cm² for VFA. When analyzed by gender, the optimal cut-off values for VFA were 98.8 cm² for males and 102.3 cm² for females. Conclusion Central obesity indicators (VFA, WHtR, WHR, WC) were associated with UACR. VFA was the strongest predictor for UACR ≥ 30 mg/g.https://doi.org/10.1186/s13098-025-01814-5Type 2 diabetes mellitusAbdominal fat distributionVisceral fat areaSubcutaneous fat areaUrinary albumin/Creatinine ratio |
| spellingShingle | Tianlu Shi Ying Yang Yunxia Liu Min Zhang Junran Shu Shujin Wang Tianxiao Zhang Yu Niu Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus Diabetology & Metabolic Syndrome Type 2 diabetes mellitus Abdominal fat distribution Visceral fat area Subcutaneous fat area Urinary albumin/Creatinine ratio |
| title | Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus |
| title_full | Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus |
| title_fullStr | Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus |
| title_short | Association between abdominal fat distribution and urinary albumin/creatinine ratio in patients with type 2 diabetes mellitus |
| title_sort | association between abdominal fat distribution and urinary albumin creatinine ratio in patients with type 2 diabetes mellitus |
| topic | Type 2 diabetes mellitus Abdominal fat distribution Visceral fat area Subcutaneous fat area Urinary albumin/Creatinine ratio |
| url | https://doi.org/10.1186/s13098-025-01814-5 |
| work_keys_str_mv | AT tianlushi associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT yingyang associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT yunxialiu associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT minzhang associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT junranshu associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT shujinwang associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT tianxiaozhang associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus AT yuniu associationbetweenabdominalfatdistributionandurinaryalbumincreatinineratioinpatientswithtype2diabetesmellitus |