Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output
Patients with cerebellar damage experience various motor impairments, but the specific sequence of primary and compensatory processes that contribute to these deficits remains unclear. To clarify this, we reversibly blocked cerebellar outflow in monkeys engaged in planar reaching tasks. This interve...
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| Format: | Article |
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eLife Sciences Publications Ltd
2025-06-01
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| Online Access: | https://elifesciences.org/articles/105152 |
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| author | Nirvik Sinha Sharon Israely Ora Ben Harosh Ran Harel Julius PA Dewald Yifat Prut |
| author_facet | Nirvik Sinha Sharon Israely Ora Ben Harosh Ran Harel Julius PA Dewald Yifat Prut |
| author_sort | Nirvik Sinha |
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| description | Patients with cerebellar damage experience various motor impairments, but the specific sequence of primary and compensatory processes that contribute to these deficits remains unclear. To clarify this, we reversibly blocked cerebellar outflow in monkeys engaged in planar reaching tasks. This intervention led to a spatially selective reduction in hand velocity, primarily due to decreased muscle torque, especially in movements requiring high inter-joint torque coupling. When examining repeated reaches to the same target, we found that the reduced velocity resulted from both an immediate deficit and a gradually developing compensatory slowing to reduce passive inter-joint interactions. However, the slowed hand velocity did not account for the fragmented and variable movement trajectories observed during the cerebellar block. Our findings indicate that cerebellar impairment results in motor deficits due to both inadequate muscle torque and an altered motor control strategy for managing impaired limb dynamics. Additionally, impaired motor control elevates noise, which cannot be entirely mitigated through compensatory strategies. |
| format | Article |
| id | doaj-art-14935c4ea6ea4d81953fc2199028ae9c |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-14935c4ea6ea4d81953fc2199028ae9c2025-08-20T03:29:38ZengeLife Sciences Publications LtdeLife2050-084X2025-06-011410.7554/eLife.105152Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar outputNirvik Sinha0https://orcid.org/0000-0001-6960-7159Sharon Israely1https://orcid.org/0000-0003-4298-7395Ora Ben Harosh2https://orcid.org/0009-0009-2587-834XRan Harel3https://orcid.org/0000-0002-0165-7114Julius PA Dewald4https://orcid.org/0000-0003-0641-8400Yifat Prut5https://orcid.org/0000-0003-1988-8794Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel; Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States; Interdepartmental Neuroscience Center, Northwestern University Feinberg School of Medicine, Chicago, United StatesEdmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelEdmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Neurosurgery, Sheba Medical Center, Tel-Hashomer Affiliated to Tel Aviv University, IsraelDepartment of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States; Interdepartmental Neuroscience Center, Northwestern University Feinberg School of Medicine, Chicago, United States; Department of Biomedical Engineering, Northwestern University, Evanston, United States; Department of Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, United StatesEdmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelPatients with cerebellar damage experience various motor impairments, but the specific sequence of primary and compensatory processes that contribute to these deficits remains unclear. To clarify this, we reversibly blocked cerebellar outflow in monkeys engaged in planar reaching tasks. This intervention led to a spatially selective reduction in hand velocity, primarily due to decreased muscle torque, especially in movements requiring high inter-joint torque coupling. When examining repeated reaches to the same target, we found that the reduced velocity resulted from both an immediate deficit and a gradually developing compensatory slowing to reduce passive inter-joint interactions. However, the slowed hand velocity did not account for the fragmented and variable movement trajectories observed during the cerebellar block. Our findings indicate that cerebellar impairment results in motor deficits due to both inadequate muscle torque and an altered motor control strategy for managing impaired limb dynamics. Additionally, impaired motor control elevates noise, which cannot be entirely mitigated through compensatory strategies.https://elifesciences.org/articles/105152macaque fasciculariscerebelluminteraction torquesmotor noiseweaknessmuscle torques |
| spellingShingle | Nirvik Sinha Sharon Israely Ora Ben Harosh Ran Harel Julius PA Dewald Yifat Prut Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output eLife macaque fascicularis cerebellum interaction torques motor noise weakness muscle torques |
| title | Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| title_full | Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| title_fullStr | Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| title_full_unstemmed | Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| title_short | Disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| title_sort | disentangling acute motor deficits and adaptive responses evoked by the loss of cerebellar output |
| topic | macaque fascicularis cerebellum interaction torques motor noise weakness muscle torques |
| url | https://elifesciences.org/articles/105152 |
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