High expression of malic enzyme 1 predicts adverse prognosis in patients with cytogenetically normal acute myeloid leukaemia and promotes leukaemogenesis through the IL-6/JAK2/STAT3 pathways

High expression of malic enzyme 1 predicts adverse prognosis in patients with cytogenetically normal acute myeloid leukaemia and promotes leukaemogenesis through the IL-6/JAK2/STAT3 pathways

Background: Progress in improving risk stratification methods for patients with cytogenetically normal acute myeloid leukaemia (CN-AML) remains limited. This study investigates the prognostic significance and potential functional mechanism of malic enzyme 1 (ME1) in CN-AML. Methods: Gene expression...

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Main Authors: Chang Zhang, Wenlu Li, Fei Wu, Zhongwei Lu, Piaorong Zeng, Zeyu Luo, Yixiong Cao, Feng Wen, Junjun Li, Xi Chen, Fujue Wang
Format: Article
Language:English
Published: SAGE Publishing 2024-11-01
Series:Therapeutic Advances in Hematology
Online Access:https://doi.org/10.1177/20406207241301948
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