Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance

Machine learning–guided single-cell multiomics uncovers GDF15-driven immunosuppressive niches in NSCLC: A translational framework for overcoming anti-PD-1 resistance

Immune checkpoint blockade (ICB) has transformed non-small cell lung cancer (NSCLC) treatment, but durable clinical responses remain limited, underscoring the need for robust predictive biomarkers. We integrated multiomics profiling with machine learning to systematically identify determinants of IC...

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Bibliographic Details
Main Authors: Xianfei Zhang, Zhengxin Yin, Xueyu Chen, Nengchong Zhang, Shengjia Yu, Congcong Zhu, Lianggang Zhu, Liulan Shao, Bin Li, Runsen Jin, Hecheng Li
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Translational Oncology
Subjects:
Lung cancer
Immunotherapy
Growth differentiation factor 15
Programmed cell death protein 1
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001901
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