Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations
In general, antimicrobial preservatives are essential components of multidose pharmaceutical formulations to prevent microbial growth and contamination, many of which contain lipophilic and poorly water-soluble drugs in need of solubilizing excipients, such as cyclodextrins (CDs). However, CDs frequ...
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| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/12/1601 |
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| author | Phatsawee Jansook Hákon Hrafn Sigurdsson Frédéric Pilotaz Thorsteinn Loftsson |
| author_facet | Phatsawee Jansook Hákon Hrafn Sigurdsson Frédéric Pilotaz Thorsteinn Loftsson |
| author_sort | Phatsawee Jansook |
| collection | DOAJ |
| description | In general, antimicrobial preservatives are essential components of multidose pharmaceutical formulations to prevent microbial growth and contamination, many of which contain lipophilic and poorly water-soluble drugs in need of solubilizing excipients, such as cyclodextrins (CDs). However, CDs frequently reduce or even abolish the antimicrobial activities of commonly used pharmaceutical preservatives. The degree of inactivation depends on the CD complexation of the preservatives, which in turn depends on their chemical structure and physiochemical properties. In general, lipophilic preservatives are more likely to be inactivated; however, CDs are also known to inactivate highly water-soluble preservatives. In some drug formulations, preservative inactivation has been offset by including excipients that possess some antimicrobial activity on their own. In this review, we explain how CDs interact with some commonly used pharmaceutical preservatives and why some preservatives are more susceptible to CD inactivation than others are. |
| format | Article |
| id | doaj-art-148e49e48bb3496e8ffe6a7de48e9c23 |
| institution | DOAJ |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-148e49e48bb3496e8ffe6a7de48e9c232025-08-20T02:43:42ZengMDPI AGPharmaceutics1999-49232024-12-011612160110.3390/pharmaceutics16121601Antimicrobial Preservatives in Cyclodextrin-Containing Drug FormulationsPhatsawee Jansook0Hákon Hrafn Sigurdsson1Frédéric Pilotaz2Thorsteinn Loftsson3Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Payathai Road, Pathumwan, Bangkok 10330, ThailandFaculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, IcelandHorus-Pharma, Département des Opérations Industrielles, 22, allée Camille-Muffat, bât. Inedi 5, 06200 Nice, FranceFaculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS-107 Reykjavik, IcelandIn general, antimicrobial preservatives are essential components of multidose pharmaceutical formulations to prevent microbial growth and contamination, many of which contain lipophilic and poorly water-soluble drugs in need of solubilizing excipients, such as cyclodextrins (CDs). However, CDs frequently reduce or even abolish the antimicrobial activities of commonly used pharmaceutical preservatives. The degree of inactivation depends on the CD complexation of the preservatives, which in turn depends on their chemical structure and physiochemical properties. In general, lipophilic preservatives are more likely to be inactivated; however, CDs are also known to inactivate highly water-soluble preservatives. In some drug formulations, preservative inactivation has been offset by including excipients that possess some antimicrobial activity on their own. In this review, we explain how CDs interact with some commonly used pharmaceutical preservatives and why some preservatives are more susceptible to CD inactivation than others are.https://www.mdpi.com/1999-4923/16/12/1601antimicrobial preservativecyclodextrininactivationantimicrobial efficacy enhancer |
| spellingShingle | Phatsawee Jansook Hákon Hrafn Sigurdsson Frédéric Pilotaz Thorsteinn Loftsson Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations Pharmaceutics antimicrobial preservative cyclodextrin inactivation antimicrobial efficacy enhancer |
| title | Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations |
| title_full | Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations |
| title_fullStr | Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations |
| title_full_unstemmed | Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations |
| title_short | Antimicrobial Preservatives in Cyclodextrin-Containing Drug Formulations |
| title_sort | antimicrobial preservatives in cyclodextrin containing drug formulations |
| topic | antimicrobial preservative cyclodextrin inactivation antimicrobial efficacy enhancer |
| url | https://www.mdpi.com/1999-4923/16/12/1601 |
| work_keys_str_mv | AT phatsaweejansook antimicrobialpreservativesincyclodextrincontainingdrugformulations AT hakonhrafnsigurdsson antimicrobialpreservativesincyclodextrincontainingdrugformulations AT fredericpilotaz antimicrobialpreservativesincyclodextrincontainingdrugformulations AT thorsteinnloftsson antimicrobialpreservativesincyclodextrincontainingdrugformulations |