First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors
Background. Primary omental leiomyosarcoma is an extremely rare type of tumor. Leiomyosarcomas originating from the lesser omentum have not been reported since immunohistochemical staining for c-kit has been used for the diagnosis of mesenchymal abdominal tumors. They are yet to be reported since ga...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2019/2426092 |
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| author | Fumito Saijo Kaoru Sato Tomoko Handa Yoichi Narushima Naoki Matsumura Noriyuki Iwama Fumie Nakayama Hiromi Tokumura |
| author_facet | Fumito Saijo Kaoru Sato Tomoko Handa Yoichi Narushima Naoki Matsumura Noriyuki Iwama Fumie Nakayama Hiromi Tokumura |
| author_sort | Fumito Saijo |
| collection | DOAJ |
| description | Background. Primary omental leiomyosarcoma is an extremely rare type of tumor. Leiomyosarcomas originating from the lesser omentum have not been reported since immunohistochemical staining for c-kit has been used for the diagnosis of mesenchymal abdominal tumors. They are yet to be reported since gastrointestinal stromal tumors were categorized. Here we reported a case of successful resection of a lesser omental leiomyosarcoma. Case Presentation. A 71-year-old man underwent ultrasonography at the outpatient clinic through which an upper abdominal tumor was identified. Following computed tomography and endoscopy, a 4.5 cm submucosal tumor in the lesser curvature of the stomach was highly suspected. A laparoscopic partial resection of the stomach was performed. Histopathological examination revealed the tumor to be a leiomyosarcoma arising from the lesser omentum that did not invade the stomach. Immunohistochemical staining showed that the tumor was negative for CD34, c-kit, and S-100 and positive for desmin and α-smooth muscle actin. No recurrence had been observed 1 year after surgery without adjuvant chemotherapy. Conclusions. Primary lesser omental leiomyosarcoma, which is difficult to diagnose before surgery given the location of the primary tumor in the lesser omentum, has rarely been reported. Considering the high possibility of malignancy, close observation is essential. |
| format | Article |
| id | doaj-art-148b0aa0c6fc4693892058fe783ea4cc |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-148b0aa0c6fc4693892058fe783ea4cc2025-02-03T01:30:05ZengWileyCase Reports in Surgery2090-69002090-69192019-01-01201910.1155/2019/24260922426092First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal TumorsFumito Saijo0Kaoru Sato1Tomoko Handa2Yoichi Narushima3Naoki Matsumura4Noriyuki Iwama5Fumie Nakayama6Hiromi Tokumura7Department of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Gastroenterology, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Pathology, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Pathology, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanDepartment of Surgery, Tohoku Rosai Hospital, 4-3-21, Dainohara, Aobaku, Sendai, Miyagi 981-8563, JapanBackground. Primary omental leiomyosarcoma is an extremely rare type of tumor. Leiomyosarcomas originating from the lesser omentum have not been reported since immunohistochemical staining for c-kit has been used for the diagnosis of mesenchymal abdominal tumors. They are yet to be reported since gastrointestinal stromal tumors were categorized. Here we reported a case of successful resection of a lesser omental leiomyosarcoma. Case Presentation. A 71-year-old man underwent ultrasonography at the outpatient clinic through which an upper abdominal tumor was identified. Following computed tomography and endoscopy, a 4.5 cm submucosal tumor in the lesser curvature of the stomach was highly suspected. A laparoscopic partial resection of the stomach was performed. Histopathological examination revealed the tumor to be a leiomyosarcoma arising from the lesser omentum that did not invade the stomach. Immunohistochemical staining showed that the tumor was negative for CD34, c-kit, and S-100 and positive for desmin and α-smooth muscle actin. No recurrence had been observed 1 year after surgery without adjuvant chemotherapy. Conclusions. Primary lesser omental leiomyosarcoma, which is difficult to diagnose before surgery given the location of the primary tumor in the lesser omentum, has rarely been reported. Considering the high possibility of malignancy, close observation is essential.http://dx.doi.org/10.1155/2019/2426092 |
| spellingShingle | Fumito Saijo Kaoru Sato Tomoko Handa Yoichi Narushima Naoki Matsumura Noriyuki Iwama Fumie Nakayama Hiromi Tokumura First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors Case Reports in Surgery |
| title | First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors |
| title_full | First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors |
| title_fullStr | First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors |
| title_full_unstemmed | First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors |
| title_short | First Account of Primary Leiomyosarcoma of the Lesser Omentum since Establishment of c-Kit Mutations in Gastrointestinal Stromal Tumors |
| title_sort | first account of primary leiomyosarcoma of the lesser omentum since establishment of c kit mutations in gastrointestinal stromal tumors |
| url | http://dx.doi.org/10.1155/2019/2426092 |
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