Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy
Abstract Sepsis-associated encephalopathy (SAE) represents a severe neurological complication in sepsis, characterized by high mortality and cognitive impairment. Although clinical significance, SAE lacks effective diagnostic and prognostic tools. This study evaluates the predictive value of neuron-...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-00353-3 |
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| author | Qian Zhang Xujie Zhang Yi Li Lingwei Zeng Runyin Zhu Yan Xin Lixia Liu Zhenjie Hu Yan Huo |
| author_facet | Qian Zhang Xujie Zhang Yi Li Lingwei Zeng Runyin Zhu Yan Xin Lixia Liu Zhenjie Hu Yan Huo |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Abstract Sepsis-associated encephalopathy (SAE) represents a severe neurological complication in sepsis, characterized by high mortality and cognitive impairment. Although clinical significance, SAE lacks effective diagnostic and prognostic tools. This study evaluates the predictive value of neuron-specific enolase (NSE) and regional cerebral oxygen saturation variability (rSO₂%) as indicators for diagnosing and prognosing SAE. A prospective observational study enrolled 70 sepsis patients, classified into SAE and non-SAE groups. Serum NSE levels and rSO₂% were measured alongside clinical data and 28-day mortality outcomes. NSE and rSO₂% were identified as independent indicators of SAE (P < 0.05). Combined analysis achieved a higher diagnostic accuracy, with an area under the ROC curve of 0.749, compared to single indicators. Kaplan-Meier survival analysis reveals that elevated NSE levels and increased rSO₂% are associated with significantly reduced 28-day survival (P < 0.001). These findings suggest that NSE and rSO₂%are valuable indicators for the diagnosis and prognosticating SAE. Their combined application significantly improves diagnostic efficacy, providing a basis for personalized early intervention strategies. |
| format | Article |
| id | doaj-art-147fa0a924304bf1a0c505197f2deaf3 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-147fa0a924304bf1a0c505197f2deaf32025-08-20T01:47:29ZengNature PortfolioScientific Reports2045-23222025-05-0115111010.1038/s41598-025-00353-3Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathyQian Zhang0Xujie Zhang1Yi Li2Lingwei Zeng3Runyin Zhu4Yan Xin5Lixia Liu6Zhenjie Hu7Yan Huo8Department of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Hebei General HospitalDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Intensive Care Unit, The Third Hospital of ShijiazhuangDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityDepartment of Intensive Care Unit, The Fourth Hospital of Hebei Medical UniversityAbstract Sepsis-associated encephalopathy (SAE) represents a severe neurological complication in sepsis, characterized by high mortality and cognitive impairment. Although clinical significance, SAE lacks effective diagnostic and prognostic tools. This study evaluates the predictive value of neuron-specific enolase (NSE) and regional cerebral oxygen saturation variability (rSO₂%) as indicators for diagnosing and prognosing SAE. A prospective observational study enrolled 70 sepsis patients, classified into SAE and non-SAE groups. Serum NSE levels and rSO₂% were measured alongside clinical data and 28-day mortality outcomes. NSE and rSO₂% were identified as independent indicators of SAE (P < 0.05). Combined analysis achieved a higher diagnostic accuracy, with an area under the ROC curve of 0.749, compared to single indicators. Kaplan-Meier survival analysis reveals that elevated NSE levels and increased rSO₂% are associated with significantly reduced 28-day survival (P < 0.001). These findings suggest that NSE and rSO₂%are valuable indicators for the diagnosis and prognosticating SAE. Their combined application significantly improves diagnostic efficacy, providing a basis for personalized early intervention strategies.https://doi.org/10.1038/s41598-025-00353-3Sepsis-associated encephalopathy(SAE)Neuron-specific enolase(NSE)Regional cerebral oxygen saturation(rSO₂)Egional cerebral oxygen saturation variability (rSO₂%)PrognosisDiagnosis |
| spellingShingle | Qian Zhang Xujie Zhang Yi Li Lingwei Zeng Runyin Zhu Yan Xin Lixia Liu Zhenjie Hu Yan Huo Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy Scientific Reports Sepsis-associated encephalopathy(SAE) Neuron-specific enolase(NSE) Regional cerebral oxygen saturation(rSO₂) Egional cerebral oxygen saturation variability (rSO₂%) Prognosis Diagnosis |
| title | Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy |
| title_full | Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy |
| title_fullStr | Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy |
| title_full_unstemmed | Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy |
| title_short | Combined cerebral oxygen saturation and neuron-specific enolase evaluation for diagnosis and prognosis of sepsis-associated encephalopathy |
| title_sort | combined cerebral oxygen saturation and neuron specific enolase evaluation for diagnosis and prognosis of sepsis associated encephalopathy |
| topic | Sepsis-associated encephalopathy(SAE) Neuron-specific enolase(NSE) Regional cerebral oxygen saturation(rSO₂) Egional cerebral oxygen saturation variability (rSO₂%) Prognosis Diagnosis |
| url | https://doi.org/10.1038/s41598-025-00353-3 |
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