Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)

The history of the study of postoperative neurocognitive disorders (PND) looks as a long and thorny path of more than 400 years. Despite all accumulated data on PND risk factors and outcomes, there’s still no complete understanding of the etiology and pathogenesis of this complication. Moreover, cur...

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Main Authors: L. B. Berikashvili, K. K. Kadantseva, N. V. Ermokhina, M. Ya. Yadgarov, D. G. Makarevich, A.  V. Smirnova, V. V. Likhvantsev
Format: Article
Language:English
Published: Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia 2023-08-01
Series:Общая реаниматология
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Online Access:https://www.reanimatology.com/rmt/article/view/2331
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author L. B. Berikashvili
K. K. Kadantseva
N. V. Ermokhina
M. Ya. Yadgarov
D. G. Makarevich
A.  V. Smirnova
V. V. Likhvantsev
author_facet L. B. Berikashvili
K. K. Kadantseva
N. V. Ermokhina
M. Ya. Yadgarov
D. G. Makarevich
A.  V. Smirnova
V. V. Likhvantsev
author_sort L. B. Berikashvili
collection DOAJ
description The history of the study of postoperative neurocognitive disorders (PND) looks as a long and thorny path of more than 400 years. Despite all accumulated data on PND risk factors and outcomes, there’s still no complete understanding of the etiology and pathogenesis of this complication. Moreover, current anesthesiologyresuscitation practice still faces challenges and has pending questions in diagnosis and classification of postoperative neurocognitive disorders.The purpose of the review. To contemplate the evolution in the perceptions of the international medical community (IMC) regarding diagnostic approaches and algorithms in PND management. The review covers the history of development of such PND concepts as postoperative delirium, postoperative cognitive dysfunction, emergence agitation and emergence delirium. Also, the pre-existing and current international classifications of postoperative neurocognitive disorders are discussed in chronological order, supplemented by the analysis of their strengths and weaknesses. The paper also delves into current viewpoints concerning the etiology of particular postoperative neurocognitive disorders, and PND potential relevance for postoperative outcomes.Conclusion. Current algorithms and modalities used for PND diagnosis, are novel but yet not ultimate for IMC in the context of continuous progress in medical practice. Early postoperative neurocognitive disorders remain the most poorly studied phenomena with no approved definitions and diagnostic modalities to identify. It is probably the time for IMC to undertake a joint effort to find answers to current unresolved questions regarding postoperative neurocognitive disorders.
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publishDate 2023-08-01
publisher Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
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spelling doaj-art-146c6cfccdc4420ebbd9872ae28ec9742025-08-20T03:35:08ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102023-08-01194294210.15360/1813-9779-2023-4-29-421914Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)L. B. Berikashvili0K. K. Kadantseva1N. V. Ermokhina2M. Ya. Yadgarov3D. G. Makarevich4A.  V. Smirnova5V. V. Likhvantsev6V. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; M. F. Vladimirsky Moscow Regional Research Clinical InstituteV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; A. S. Loginov Moscow Clinical Research Center, Moscow Department of HealthV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyDemikhov City Clinical Hospital, Moscow City Health DepartmentV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and RehabilitologyV. A. Negovsky Research Institute of General Reanimatology, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; I. M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaThe history of the study of postoperative neurocognitive disorders (PND) looks as a long and thorny path of more than 400 years. Despite all accumulated data on PND risk factors and outcomes, there’s still no complete understanding of the etiology and pathogenesis of this complication. Moreover, current anesthesiologyresuscitation practice still faces challenges and has pending questions in diagnosis and classification of postoperative neurocognitive disorders.The purpose of the review. To contemplate the evolution in the perceptions of the international medical community (IMC) regarding diagnostic approaches and algorithms in PND management. The review covers the history of development of such PND concepts as postoperative delirium, postoperative cognitive dysfunction, emergence agitation and emergence delirium. Also, the pre-existing and current international classifications of postoperative neurocognitive disorders are discussed in chronological order, supplemented by the analysis of their strengths and weaknesses. The paper also delves into current viewpoints concerning the etiology of particular postoperative neurocognitive disorders, and PND potential relevance for postoperative outcomes.Conclusion. Current algorithms and modalities used for PND diagnosis, are novel but yet not ultimate for IMC in the context of continuous progress in medical practice. Early postoperative neurocognitive disorders remain the most poorly studied phenomena with no approved definitions and diagnostic modalities to identify. It is probably the time for IMC to undertake a joint effort to find answers to current unresolved questions regarding postoperative neurocognitive disorders.https://www.reanimatology.com/rmt/article/view/2331postoperative neurocognitive disordersdeliriumpostoperative deliriumemergence deliriumagitationspostoperative cognitive dysfunctiondelayed neurocognitive recoveryclassifications
spellingShingle L. B. Berikashvili
K. K. Kadantseva
N. V. Ermokhina
M. Ya. Yadgarov
D. G. Makarevich
A.  V. Smirnova
V. V. Likhvantsev
Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
Общая реаниматология
postoperative neurocognitive disorders
delirium
postoperative delirium
emergence delirium
agitations
postoperative cognitive dysfunction
delayed neurocognitive recovery
classifications
title Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
title_full Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
title_fullStr Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
title_full_unstemmed Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
title_short Postoperative Neurocognitive Disorders: the Legacy of Almost 400 Years of History (Review)
title_sort postoperative neurocognitive disorders the legacy of almost 400 years of history review
topic postoperative neurocognitive disorders
delirium
postoperative delirium
emergence delirium
agitations
postoperative cognitive dysfunction
delayed neurocognitive recovery
classifications
url https://www.reanimatology.com/rmt/article/view/2331
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