Clinical Traits of SARS-CoV-2 Infection
Aim. Analysis of clinical manifestations, laboratory and instrumental examination data in SARS-CoV-2 patients with taking into account the disease severity and outcome.Materials and methods. The study included 92 patients with confirmed coronavirus infection, including 15 lethal cases, hospitalised a...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2020-12-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/502 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860105176678400 |
|---|---|
| author | O. Yu. Zolnikova N. L. Dzhakhaya N. D. Potskherashvili K. B. Puzakov O. Yu. Кiseleva N. I. Kokina E. R. Buklis T. V. Roshchina I. I. Коmkova |
| author_facet | O. Yu. Zolnikova N. L. Dzhakhaya N. D. Potskherashvili K. B. Puzakov O. Yu. Кiseleva N. I. Kokina E. R. Buklis T. V. Roshchina I. I. Коmkova |
| author_sort | O. Yu. Zolnikova |
| collection | DOAJ |
| description | Aim. Analysis of clinical manifestations, laboratory and instrumental examination data in SARS-CoV-2 patients with taking into account the disease severity and outcome.Materials and methods. The study included 92 patients with confirmed coronavirus infection, including 15 lethal cases, hospitalised at the Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology of the Sechenov University in April 2020. The analysis included demographic data, the presence of concomitant diseases, chest computed tomography (CT) results, laboratory tests (including SARS-CoV-2-diagnostic PCR, general and metabolic blood panels, coagulogram) and the duration of disease.Results. Patients infected with SARS-CoV-2 usually exhibit lymphopenia (p ≤ 0.001), leucocytosis, the elevated neutrophils (p ≤ 0.05), neutrophil-lymphocyte ratio (p ≤0,05), C-reactive protein (p ≤ 0.05), ferritin (p ≤ 0.05), D-dimer (p ≤ 0.05) and fibrinogen (p ≤ 0.05), altered prothrombin time (p ≤ 0.05) and INR (p ≤ 0.05). In a critical coronavirus infection, the pulmonary lesion exceeds 50% (corresponds to CT3 — CT4). The risk of critical SARS-CoV-2 infection increases with elder age (p ≤ 0.001), associates with the male gender and presence of concomitant diseases, such as obesity (p < 0.01), diabetes mellitus (p < 0.001), hypertension (p ≤ 0.001), CHD (p ≤ 0.001) and atrial fibrillation (p <0.05).Conclusion. The risk of severe and adverse coronavirus infection is significantly higher in elder comorbid patients. |
| format | Article |
| id | doaj-art-1469954fbaf74241977b6f4d7345d7b8 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2020-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-1469954fbaf74241977b6f4d7345d7b82025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732020-12-01306283910.22416/1382-4376-2020-30-6-28-39402Clinical Traits of SARS-CoV-2 InfectionO. Yu. Zolnikova0N. L. Dzhakhaya1N. D. Potskherashvili2K. B. Puzakov3O. Yu. Кiseleva4N. I. Kokina5E. R. Buklis6T. V. Roshchina7I. I. Коmkova8Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Aim. Analysis of clinical manifestations, laboratory and instrumental examination data in SARS-CoV-2 patients with taking into account the disease severity and outcome.Materials and methods. The study included 92 patients with confirmed coronavirus infection, including 15 lethal cases, hospitalised at the Vasilenko Clinic of Internal Disease Propaedeutics, Gastroenterology and Hepatology of the Sechenov University in April 2020. The analysis included demographic data, the presence of concomitant diseases, chest computed tomography (CT) results, laboratory tests (including SARS-CoV-2-diagnostic PCR, general and metabolic blood panels, coagulogram) and the duration of disease.Results. Patients infected with SARS-CoV-2 usually exhibit lymphopenia (p ≤ 0.001), leucocytosis, the elevated neutrophils (p ≤ 0.05), neutrophil-lymphocyte ratio (p ≤0,05), C-reactive protein (p ≤ 0.05), ferritin (p ≤ 0.05), D-dimer (p ≤ 0.05) and fibrinogen (p ≤ 0.05), altered prothrombin time (p ≤ 0.05) and INR (p ≤ 0.05). In a critical coronavirus infection, the pulmonary lesion exceeds 50% (corresponds to CT3 — CT4). The risk of critical SARS-CoV-2 infection increases with elder age (p ≤ 0.001), associates with the male gender and presence of concomitant diseases, such as obesity (p < 0.01), diabetes mellitus (p < 0.001), hypertension (p ≤ 0.001), CHD (p ≤ 0.001) and atrial fibrillation (p <0.05).Conclusion. The risk of severe and adverse coronavirus infection is significantly higher in elder comorbid patients.https://www.gastro-j.ru/jour/article/view/502coronavirus infectioncytokine stormconcomitant diseasescomputed tomographylymphopeniad-dimer |
| spellingShingle | O. Yu. Zolnikova N. L. Dzhakhaya N. D. Potskherashvili K. B. Puzakov O. Yu. Кiseleva N. I. Kokina E. R. Buklis T. V. Roshchina I. I. Коmkova Clinical Traits of SARS-CoV-2 Infection Российский журнал гастроэнтерологии, гепатологии, колопроктологии coronavirus infection cytokine storm concomitant diseases computed tomography lymphopenia d-dimer |
| title | Clinical Traits of SARS-CoV-2 Infection |
| title_full | Clinical Traits of SARS-CoV-2 Infection |
| title_fullStr | Clinical Traits of SARS-CoV-2 Infection |
| title_full_unstemmed | Clinical Traits of SARS-CoV-2 Infection |
| title_short | Clinical Traits of SARS-CoV-2 Infection |
| title_sort | clinical traits of sars cov 2 infection |
| topic | coronavirus infection cytokine storm concomitant diseases computed tomography lymphopenia d-dimer |
| url | https://www.gastro-j.ru/jour/article/view/502 |
| work_keys_str_mv | AT oyuzolnikova clinicaltraitsofsarscov2infection AT nldzhakhaya clinicaltraitsofsarscov2infection AT ndpotskherashvili clinicaltraitsofsarscov2infection AT kbpuzakov clinicaltraitsofsarscov2infection AT oyukiseleva clinicaltraitsofsarscov2infection AT nikokina clinicaltraitsofsarscov2infection AT erbuklis clinicaltraitsofsarscov2infection AT tvroshchina clinicaltraitsofsarscov2infection AT iikomkova clinicaltraitsofsarscov2infection |