Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells

Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells

The rate of spontaneous action potentials (APs) generated by sinoatrial node cells (SANC) is regulated by local Ca<sup>2+</sup> release (LCR) from the sarcoplasmic reticulum via Ca<sup>2+</sup> release channels (ryanodine receptors, RyRs). LCR events propagate and self-organi...

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Main Authors: Alexander V. Maltsev, Valeria Ventura Subirachs, Oliver Monfredi, Magdalena Juhaszova, Pooja Ajay Warrier, Shardul Rakshit, Syevda Tagirova, Anna V. Maltsev, Michael D. Stern, Edward G. Lakatta, Victor A. Maltsev
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
β adrenergic stimulation
numerical model
pacemaker function
ryanodine receptor
sinoatrial node
Online Access:https://www.mdpi.com/2073-4409/13/22/1885
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