Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity
PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARγ action on insulin sensitivity. PPARγ activation in mature adipocytes induces...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2009/818945 |
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| _version_ | 1832550256546414592 |
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| author | Anna Leonardini Luigi Laviola Sebastio Perrini Annalisa Natalicchio Francesco Giorgino |
| author_facet | Anna Leonardini Luigi Laviola Sebastio Perrini Annalisa Natalicchio Francesco Giorgino |
| author_sort | Anna Leonardini |
| collection | DOAJ |
| description | PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARγ action on insulin sensitivity. PPARγ activation in mature adipocytes induces the expression of a number of genes involved in the insulin signaling cascade, thereby improving insulin sensitivity. PPARγ is the master regulator of adipogenesis, thereby stimulating the production of small insulin-sensitive adipocytes. In addition to its importance in adipogenesis, PPARγ plays an important role in regulating lipid, metabolism in mature adipocytes by increasing fatty acid trapping. Finally, adipose tissue produces several cytokines that regulate energy homeostasis, lipid and glucose metabolism. Disturbances in the production of these factors may contribute to metabolic abnormalities, and PPARγ activation is also associated with beneficial effects on expression and secretion of a whole range of cytokines. |
| format | Article |
| id | doaj-art-14601aae73614ddea2a08f545ce5c4fc |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-14601aae73614ddea2a08f545ce5c4fc2025-02-03T06:07:10ZengWileyPPAR Research1687-47571687-47652009-01-01200910.1155/2009/818945818945Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin SensitivityAnna Leonardini0Luigi Laviola1Sebastio Perrini2Annalisa Natalicchio3Francesco Giorgino4Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, ItalySection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, ItalySection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, ItalySection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, ItalySection of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari School of Medicine, Piazza Giulio Cesare, 11, 70124 Bari, ItalyPPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARγ action on insulin sensitivity. PPARγ activation in mature adipocytes induces the expression of a number of genes involved in the insulin signaling cascade, thereby improving insulin sensitivity. PPARγ is the master regulator of adipogenesis, thereby stimulating the production of small insulin-sensitive adipocytes. In addition to its importance in adipogenesis, PPARγ plays an important role in regulating lipid, metabolism in mature adipocytes by increasing fatty acid trapping. Finally, adipose tissue produces several cytokines that regulate energy homeostasis, lipid and glucose metabolism. Disturbances in the production of these factors may contribute to metabolic abnormalities, and PPARγ activation is also associated with beneficial effects on expression and secretion of a whole range of cytokines.http://dx.doi.org/10.1155/2009/818945 |
| spellingShingle | Anna Leonardini Luigi Laviola Sebastio Perrini Annalisa Natalicchio Francesco Giorgino Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity PPAR Research |
| title | Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity |
| title_full | Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity |
| title_fullStr | Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity |
| title_full_unstemmed | Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity |
| title_short | Cross-Talk between PPARγ and Insulin Signaling and Modulation of Insulin Sensitivity |
| title_sort | cross talk between pparγ and insulin signaling and modulation of insulin sensitivity |
| url | http://dx.doi.org/10.1155/2009/818945 |
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