Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors
Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to regulate cell proliferation, migration, cytoske...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.182 |
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| _version_ | 1832551513685229568 |
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| author | Nicholas Young James R. Van Brocklyn |
| author_facet | Nicholas Young James R. Van Brocklyn |
| author_sort | Nicholas Young |
| collection | DOAJ |
| description | Sphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to regulate cell proliferation, migration, cytoskeletal organization, and differentiation. These receptors are expressed in a wide variety of tissues and cell types, and their cellular effects contribute to important biological and pathological functions of S1P in many processes, including angiogenesis, vascular development, lymphocyte trafficking, and cancer. This review will focus on the current progress in the field of S1P receptor signaling and biology. |
| format | Article |
| id | doaj-art-1455a63e179d4964ac4b89541a787da9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1455a63e179d4964ac4b89541a787da92025-02-03T06:01:15ZengWileyThe Scientific World Journal1537-744X2006-01-01694696610.1100/tsw.2006.182Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled ReceptorsNicholas Young0James R. Van Brocklyn1Integrated Biomedical Science Graduate Program, Ohio State University, Columbus, USADepartment of Pathology, Ohio State University, Columbus, USASphingosine-1-phosphate (S1P) is a bioactive lipid capable of eliciting dramatic effects in a variety of cell types. Signaling by this molecule is by a family of five G protein—coupled receptors named S1P1–5 that signal through a variety of pathways to regulate cell proliferation, migration, cytoskeletal organization, and differentiation. These receptors are expressed in a wide variety of tissues and cell types, and their cellular effects contribute to important biological and pathological functions of S1P in many processes, including angiogenesis, vascular development, lymphocyte trafficking, and cancer. This review will focus on the current progress in the field of S1P receptor signaling and biology.http://dx.doi.org/10.1100/tsw.2006.182 |
| spellingShingle | Nicholas Young James R. Van Brocklyn Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors The Scientific World Journal |
| title | Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors |
| title_full | Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors |
| title_fullStr | Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors |
| title_full_unstemmed | Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors |
| title_short | Signal Transduction of Sphingosine-1-Phosphate G Protein—Coupled Receptors |
| title_sort | signal transduction of sphingosine 1 phosphate g protein coupled receptors |
| url | http://dx.doi.org/10.1100/tsw.2006.182 |
| work_keys_str_mv | AT nicholasyoung signaltransductionofsphingosine1phosphategproteincoupledreceptors AT jamesrvanbrocklyn signaltransductionofsphingosine1phosphategproteincoupledreceptors |