Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning
Abstract Throughout evolution, protein families undergo substantial sequence divergence while preserving structure and function. Although most mutations are deleterious, evolution can explore sequence space via epistatic networks of intramolecular interactions that alleviate the harmful mutations. H...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-52614-w |
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