Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management
Mysterious aspects of the long presumed to be well-known hepatitis E virus (HEV) have recently surfaced that distinguish it from other hepatotropic viruses. It is a cause of chronic hepatitis in immunosuppressed patients. It has human to human transmission through blood and mantains high seroprevale...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2015/872431 |
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| author | Aftab Ahmed Ijlal Akbar Ali Hira Ghazal Javid Fazili Salman Nusrat |
| author_facet | Aftab Ahmed Ijlal Akbar Ali Hira Ghazal Javid Fazili Salman Nusrat |
| author_sort | Aftab Ahmed |
| collection | DOAJ |
| description | Mysterious aspects of the long presumed to be well-known hepatitis E virus (HEV) have recently surfaced that distinguish it from other hepatotropic viruses. It is a cause of chronic hepatitis in immunosuppressed patients. It has human to human transmission through blood and mantains high seroprevalence in blood donors. HEV has also been found to occur more frequently in the West in those without a history of travel to endemic countries. It has varied extrahepatic manifestations and has multiple non-human reservoirs including pigs and rats. Considering these recent discoveries, it appears odd that HEV is not sought more frequently when working up acute and chronic hepatitis patients. The disease is particularly severe among pregnant women and has a high attack rate in young adults. What adds to its ambiguity is the absence of a well-established diagnostic criteria for its detection and that there is no specific antiviral drug for hepatitis E, except for isolated cases where ribavirin or pegylated interferon alpha has been used with occasional success. This review paper discusses the recent advances in the knowledge of the virus itself, its epidemiology, diagnostic approach and prevention, and the treatment options available. |
| format | Article |
| id | doaj-art-1446b5b6f8704c2fa2f5c81c1ecadd84 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-1446b5b6f8704c2fa2f5c81c1ecadd842025-08-20T03:54:33ZengWileyInternational Journal of Hepatology2090-34482090-34562015-01-01201510.1155/2015/872431872431Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and ManagementAftab Ahmed0Ijlal Akbar Ali1Hira Ghazal2Javid Fazili3Salman Nusrat4Department of Internal Medicine, Oklahoma University Health Sciences Center, Williams Pavilion 1130, P.O. Box 26901, Oklahoma City, OK 73104, USADepartment of Internal Medicine, Oklahoma University Health Sciences Center, Williams Pavilion 1130, P.O. Box 26901, Oklahoma City, OK 73104, USADow Medical College, Mission Road, Karachi 74200, PakistanSection of Digestive Diseases and Nutrition, Oklahoma University Health Sciences Center, Williams Pavilion 1345, 920 SL Young Boulevard, Oklahoma City, OK 73104, USASection of Digestive Diseases and Nutrition, Oklahoma University Health Sciences Center, Williams Pavilion 1345, 920 SL Young Boulevard, Oklahoma City, OK 73104, USAMysterious aspects of the long presumed to be well-known hepatitis E virus (HEV) have recently surfaced that distinguish it from other hepatotropic viruses. It is a cause of chronic hepatitis in immunosuppressed patients. It has human to human transmission through blood and mantains high seroprevalence in blood donors. HEV has also been found to occur more frequently in the West in those without a history of travel to endemic countries. It has varied extrahepatic manifestations and has multiple non-human reservoirs including pigs and rats. Considering these recent discoveries, it appears odd that HEV is not sought more frequently when working up acute and chronic hepatitis patients. The disease is particularly severe among pregnant women and has a high attack rate in young adults. What adds to its ambiguity is the absence of a well-established diagnostic criteria for its detection and that there is no specific antiviral drug for hepatitis E, except for isolated cases where ribavirin or pegylated interferon alpha has been used with occasional success. This review paper discusses the recent advances in the knowledge of the virus itself, its epidemiology, diagnostic approach and prevention, and the treatment options available.http://dx.doi.org/10.1155/2015/872431 |
| spellingShingle | Aftab Ahmed Ijlal Akbar Ali Hira Ghazal Javid Fazili Salman Nusrat Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management International Journal of Hepatology |
| title | Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management |
| title_full | Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management |
| title_fullStr | Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management |
| title_full_unstemmed | Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management |
| title_short | Mystery of Hepatitis E Virus: Recent Advances in Its Diagnosis and Management |
| title_sort | mystery of hepatitis e virus recent advances in its diagnosis and management |
| url | http://dx.doi.org/10.1155/2015/872431 |
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