HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

HMGA2 and protein leucine methylation drive pancreatic cancer lineage plasticity

Abstract Basal pancreatic ductal adenocarcinoma (PDAC) has the worst overall survival and is the only subtype that serves as an independent poor prognostic factor. We identify elevated levels of LIN28B and its downstream target, HMGA2, in basal PDAC. Notably, LIN28B significantly accelerates KRAS-dr...

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Main Authors: Stephanie Dobersch, Naomi Yamamoto, Aidan Schutter, Sarah M. Cavender, Tess M. Robertson, Nithya Kartha, Annie N. Samraj, Ben Doron, Lisa A. Poole, Cynthia L. Wladyka, Amy Zhang, Gun Ho Jang, Aswanth H. Mahalingam, Guillermo Barreto, Srivatsan Raghavan, Goutham Narla, Faiyaz Notta, Robert N. Eisenman, Andrew C. Hsieh, Sita Kugel
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60129-1
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