Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis
Chronic hepatitis C virus (HCV) infection may eventually lead to progressive liver fibrosis and cirrhosis through a complex, multistep process involving hepatocyte death and regeneration. Despite common pathogenetic pathways present in all forms of liver cirrhosis irrespective of etiology, hepatocyt...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/654105 |
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| author | Nikolaos P. Karidis Ioanna Delladetsima Stamatios Theocharis |
| author_facet | Nikolaos P. Karidis Ioanna Delladetsima Stamatios Theocharis |
| author_sort | Nikolaos P. Karidis |
| collection | DOAJ |
| description | Chronic hepatitis C virus (HCV) infection may eventually lead to progressive liver fibrosis and cirrhosis through a complex, multistep process involving hepatocyte death and regeneration. Despite common pathogenetic pathways present in all forms of liver cirrhosis irrespective of etiology, hepatocyte turnover and related molecular events in HCV-induced cirrhosis are increasingly being distinguished from even “similar” causes, such as hepatitis B virus- (HBV-) related cirrhosis. New insights in HCV-induced hepatocellular injury, differential gene expression, and regenerative pathways have recently revealed a different pattern of progression to irreversible parenchymal liver damage. A shift to the significant role of the host immune response rather than the direct effect of HCV on hepatocytes and the imbalance between antiapoptotic and proapoptotic signals have been investigated in several studies but need to be further elucidated. The present review aims to comprehensively summarize the current evidence on HCV-induced hepatocellular turnover with a view to outline the significant trends of ongoing research. |
| format | Article |
| id | doaj-art-14451ecdfaa8461598e68758d881f75b |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-14451ecdfaa8461598e68758d881f75b2025-02-03T06:06:07ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/654105654105Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and CirrhosisNikolaos P. Karidis0Ioanna Delladetsima1Stamatios Theocharis2First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, 11527 Athens, GreeceChronic hepatitis C virus (HCV) infection may eventually lead to progressive liver fibrosis and cirrhosis through a complex, multistep process involving hepatocyte death and regeneration. Despite common pathogenetic pathways present in all forms of liver cirrhosis irrespective of etiology, hepatocyte turnover and related molecular events in HCV-induced cirrhosis are increasingly being distinguished from even “similar” causes, such as hepatitis B virus- (HBV-) related cirrhosis. New insights in HCV-induced hepatocellular injury, differential gene expression, and regenerative pathways have recently revealed a different pattern of progression to irreversible parenchymal liver damage. A shift to the significant role of the host immune response rather than the direct effect of HCV on hepatocytes and the imbalance between antiapoptotic and proapoptotic signals have been investigated in several studies but need to be further elucidated. The present review aims to comprehensively summarize the current evidence on HCV-induced hepatocellular turnover with a view to outline the significant trends of ongoing research.http://dx.doi.org/10.1155/2015/654105 |
| spellingShingle | Nikolaos P. Karidis Ioanna Delladetsima Stamatios Theocharis Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis Gastroenterology Research and Practice |
| title | Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis |
| title_full | Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis |
| title_fullStr | Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis |
| title_full_unstemmed | Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis |
| title_short | Hepatocyte Turnover in Chronic HCV-Induced Liver Injury and Cirrhosis |
| title_sort | hepatocyte turnover in chronic hcv induced liver injury and cirrhosis |
| url | http://dx.doi.org/10.1155/2015/654105 |
| work_keys_str_mv | AT nikolaospkaridis hepatocyteturnoverinchronichcvinducedliverinjuryandcirrhosis AT ioannadelladetsima hepatocyteturnoverinchronichcvinducedliverinjuryandcirrhosis AT stamatiostheocharis hepatocyteturnoverinchronichcvinducedliverinjuryandcirrhosis |