LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.

LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.

Fungal pathogens elicit cytokine responses downstream of immunoreceptor tyrosine-based activation motif (ITAM)-coupled or hemiITAM-containing receptors and TLRs. The Linker for Activation of B cells/Non-T cell Activating Linker (LAB/NTAL) encoded by Lat2, is a known regulator of ITAM-coupled recepto...

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Main Authors: Selinda J Orr, Ashley R Burg, Tim Chan, Laura Quigley, Gareth W Jones, Jill W Ford, Deborah Hodge, Catherine Razzook, Joseph Sarhan, Yava L Jones, Gillian C Whittaker, Kimberly C Boelte, Lyudmila Lyakh, Marco Cardone, Geraldine M O'Connor, Cuiyan Tan, Hongchuan Li, Stephen K Anderson, Simon A Jones, Weiguo Zhang, Philip R Taylor, Giorgio Trinchieri, Daniel W McVicar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003357&type=printable
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