The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure
The present review includes data on efficacy and safety of pomalidomide, an immunomodulating 3rd generation drug used for treatment of relapsed and refractory multiple myeloma patients with renal failure. The results of multicenter randomized trials proved similar efficacy and comparable safety prof...
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| Format: | Article |
| Language: | Russian |
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Practical Medicine Publishing House
2018-10-01
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| Series: | Клиническая онкогематология |
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| Online Access: | http://bloodjournal.ru/wp-content/uploads/2018/09/1-1.pdf |
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| author | IG Rekhtina MV Nareiko LP Mendeleeva |
| author_facet | IG Rekhtina MV Nareiko LP Mendeleeva |
| author_sort | IG Rekhtina |
| collection | DOAJ |
| description | The present review includes data on efficacy and safety of pomalidomide, an immunomodulating 3rd generation drug used for treatment of relapsed and refractory multiple myeloma patients with renal failure. The results of multicenter randomized trials proved similar efficacy and comparable safety profile in patients with normal renal function and patients with moderate and/or severe renal failure. All patients received the standard starting dose. Pomalidomide dose needs to be reduced in response to hematological toxicity. The paper provides practical guidelines on the use of pomalidomide and treatment of adverse events adopted by consensus of international experts. Current approaches to multiple myeloma with renal failure, and the use of pomalidomide in particular, are demonstrated by means of a clinical case. |
| format | Article |
| id | doaj-art-143cf34edc5942a08a9ff47ce4bd76b8 |
| institution | OA Journals |
| issn | 1997-6933 2500-2139 |
| language | Russian |
| publishDate | 2018-10-01 |
| publisher | Practical Medicine Publishing House |
| record_format | Article |
| series | Клиническая онкогематология |
| spelling | doaj-art-143cf34edc5942a08a9ff47ce4bd76b82025-08-20T01:59:04ZrusPractical Medicine Publishing HouseКлиническая онкогематология1997-69332500-21392018-10-0111428328710.21320/2500-2139-2018-11-4-283-287The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal FailureIG Rekhtina0MV Nareiko1 LP Mendeleeva2National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167National Research Center for Hematology, 4 Novyi Zykovskii pr-d, Moscow, Russian Federation, 125167The present review includes data on efficacy and safety of pomalidomide, an immunomodulating 3rd generation drug used for treatment of relapsed and refractory multiple myeloma patients with renal failure. The results of multicenter randomized trials proved similar efficacy and comparable safety profile in patients with normal renal function and patients with moderate and/or severe renal failure. All patients received the standard starting dose. Pomalidomide dose needs to be reduced in response to hematological toxicity. The paper provides practical guidelines on the use of pomalidomide and treatment of adverse events adopted by consensus of international experts. Current approaches to multiple myeloma with renal failure, and the use of pomalidomide in particular, are demonstrated by means of a clinical case.http://bloodjournal.ru/wp-content/uploads/2018/09/1-1.pdfpomalidomidemultiple myelomarenal failure |
| spellingShingle | IG Rekhtina MV Nareiko LP Mendeleeva The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure Клиническая онкогематология pomalidomide multiple myeloma renal failure |
| title | The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure |
| title_full | The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure |
| title_fullStr | The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure |
| title_full_unstemmed | The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure |
| title_short | The Use of Pomalidomide in the Treatment of Relapsed/Refractory Multiple Myeloma in Patients with Renal Failure |
| title_sort | use of pomalidomide in the treatment of relapsed refractory multiple myeloma in patients with renal failure |
| topic | pomalidomide multiple myeloma renal failure |
| url | http://bloodjournal.ru/wp-content/uploads/2018/09/1-1.pdf |
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